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Halofantrine HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: Rarely, this medication has caused serious, sometimes fatal heart problems (e.g., ventricular arrhythmias), even at recommended doses. Halofantrine is not recommended for use while using other medications known to cause heart problems (e.g., prolonged QT interval), nor in people who have ever used mefloquine. Halofantrine is not recommended for use if you have a history of heart problems or have had unexplained fainting episodes. Your doctor will monitor you closely while you are using this medication.


This medication is used to treat malaria.

How To Use

Take this medication by mouth on an empty stomach, 1 hour before or 2 hours after food, generally every 6 hours for 3 doses as directed by your physician. Do not take with food. Taking this drug with food will increase the side effects. Dosage is based on your medical condition and response to therapy. Do not exceed the recommended dose of this medication, as serious side effects may occur.

Side Effects

Diarrhea, nausea, vomiting, stomach pain, loss of appetite, dizziness and headache may occur. If these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if you have any of these unlikely but serious side effects: cough, muscle pain, tremors. Tell your doctor immediately if you have any of these very unlikely but serious side effects: chest pain, mental/mood changes, convulsions. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fast/slow/irregular heartbeat, fainting. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other side effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, including: allergies, heart disease (e.g., arrhythmias or heart conduction disorders such as QT prolongation), family history of heart disease (e.g., arrhythmias), unexplained fainting. This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription drugs you may use, especially of: mefloquine (or if you have previously taken mefloquine). Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, quinidine, sotalol, procainamide, sparfloxacin, "water pills" (diuretics such as furosemide or hydrochlorothiazide). Ask your doctor or pharmacist for more details. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include stomach pain, vomiting, cramping, diarrhea, and irregular heartbeat.


Do not share this medication with others. Laboratory or medical tests may be performed to monitor your progress. Your heart rhythm (ECG) will be monitored during and for 8 to 12 hours after therapy.

Missed Dose

It is important not to miss any doses. However, if you do miss a dose, contact your doctor or pharmacist promptly to establish a new dosing schedule.


Store at room temperature between 68 to 77 degrees F (20 to 25 degrees C) away from light and moisture.