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Glimepiride oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Glimepiride is used along with diet to treat diabetes. It can be used with insulin or metformin in certain cases. Controlling high blood sugar helps prevent heart disease, strokes, kidney disease, circulation problems, and blindness.

How To Use

Take this by mouth exactly as prescribed, usually once a day with breakfast or the first main meal of the day. Your dose may be adjusted initially every 1-2 weeks to determine the most effective dose for you. Follow dosing instructions closely and keep all doctors appointments. It is important that you regularly test your urine or blood for sugar as discussed with your doctor.

Side Effects

Stomach pain, gas, bloating or diarrhea are most common but should subside as your body adjusts to the medication. Also, skin rash/itching, dizziness and nausea may occur. Sun sensitivity/rash occurs rarely. If any of these effects continue or become severe, inform your doctor. Notify your doctor if you develop: symptoms of high blood sugar (e.g., thirst, frequent urination), symptoms of low blood sugar (e.g., increased heart rate, nervousness, sweating, hunger, numbness/tingling of the hands or feet). Promptly report any of these serious side effects: persistent sore throat or fever, unusual bruises/bleeding, headache, shortness of breath, yellowing skin or eyes (jaundice). If you notice other effects not listed above, contact your doctor or pharmacist.


Before taking this drug, tell your doctor if you have been hospitalized for diabetes or have any of the following medical problems: kidney disease, liver disease, heart disease, any allergies. During times of stress such as fever, infection, injury or surgery, it may be more difficult to control your blood sugar. Consult your doctor or pharmacist as additional medication may be required. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug is excreted into breast milk. Other similar drugs are excreted into breast milk. Consult with your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any nonprescription or prescription medication you may take particularly: "water pills" (diuretics), thyroid hormone, steroids, estrogen hormone, sulfa drugs, azole-type antifungals (e.g., itraconazole, ketoconazole), quinolone antibiotics (e.g., ciprofloxacin, levofloxacin), birth control pills, phenytoin, isoniazid, aspirin or aspirin-like drugs (e.g., NSAIDs), "blood thinners" (e.g., warfarin), asparaginase, MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine), phenothiazines (e.g., chlorpromazine, thioridazine), H2-blockers (e.g., famotidine, ranitidine), pentamidine, octreotide, cyclosporine, beta-blockers (e.g., metoprolol, propranolol). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include lightheadedness, sweating, rapid pulse, tremor, confusion, seizures, and loss of consciousness.


Do not share this medication with others. It is recommended you attend a diabetes education program to understand diabetes and all important aspects of its treatment including meals/diet, exercise, personal hygiene, medications and getting regular eye, foot and medical exams. Consult your doctor or pharmacist. Keep all medical appointments. Laboratory and/or medical tests (e.g., liver and kidney function tests, fasting blood glucose, hemoglobin A1c, complete blood counts) will be performed to monitor for side effects and response to therapy. Regularly check your blood or urine for sugar, as directed by your doctor or pharmacist.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store this at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).