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Estrogens,conjugated and Meprobamate oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(ESS-trow-jens WITH meh-PRO-buh-mate)

WARNING: This drug has been reported to increase the chance of womb (endometrial) cancer in women who have been through menopause. This risk appears to depend on the length of time this drug is used and the amount of estrogen per dose. If you use this drug for an extended period, you should be evaluated at least every 6 months. If you experience abnormal vaginal bleeding, notify your doctor promptly. This medication is not effective in preventing or treating a tendency toward miscarriages (natural habitual abortion) nor the threat of miscarriage. This drug must not be used during pregnancy because its use may result in birth defects or cancer later in the child's life. If you become pregnant or think you may be pregnant, consult your doctor immediately to discuss the risk to the fetus.


Estrogens are used to relieve symptoms of menopause. Meprobamate is used to treat anxiety, tension and stress.

How To Use

Take this medication by mouth as directed, usually three times a day for 21 days followed by 1 week of no medication. Do not increase your dose or take this more often than prescribed without consulting your doctor.

Side Effects

Stomach upset, nausea, bloating, headache, breast tenderness, drowsiness, dizziness and blurred vision may occur the first several days as your body adjusts to the medication. Weakness, swelling of the hands or feet, changes in sexual desire, change in weight may also occur. If any of these effects persist or worsen, inform your doctor. Notify your doctor if you develop: chest pain, rapid heart rate, jaundice, stomach cramps, vomiting, depression, breathing trouble, unusual bleeding or bruising, pain in legs, lumps in the breast, numbness in the arms/legs, fever/sore throat, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: liver disease, kidney disease, breast cancer, blood disorders, gallbladder disease, diabetes, seizure disorder, drug dependency, depression, any allergies. Depending on strength, this drug may cause a patchy, darkening of the skin on the face (melasma). Higher strengths are more likely to cause melasma. Sunlight may intensify this darkening and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding use of sunscreens and protective clothing. Smoking may increase the risk of side effects of this medication. Be sure your doctor knows if you smoke. Discuss the risks. Since this medication may cause drowsiness, dizziness or blurred vision, use caution operating machinery and limit intake of alcoholic beverages. This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. The meprobamate in this combination medicine is excreted into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take especially of: sedatives, sleeping agents, narcotic pain relievers, blood thinners, medication for depression, steroids, dantrolene, thyroid drugs. This product can affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


It is important to understand the risks and benefits of this medication. Be sure to discuss them with your doctor.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.