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Estramustine phosphate sodium oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(ess-TRAM-you-steen FOSS fate)



This is an anticancer medication used to treat prostate cancer.

How To Use

This medication is taken by mouth as directed. This is best taken with a full glass (8 oz or 240 ml) of water one hour before or two hours after meals unless your doctor directs you otherwise. Do not lie down for 30 minutes after taking this medication. Avoid intake of milk, dairy products and calcium-rich foods or medications concurrently with this medication. The absorption of the drug will be affected. Make sure you understand your dosing schedule and follow it closely. Do not take this medication more often or skip any doses unless directed to do so by your doctor.

Side Effects

This medication may cause nausea, vomiting, loss of appetite, gas, flushing, dry skin, headache, thinning hair, breast enlargement, irritated throat or hoarseness. If these symptoms continue or become bothersome, inform your doctor. Notify your doctor if you develop: dark stools, stomach pains, easy bruising or bleeding, breathing difficulty, chest pain, skin rash, itching, weakness, swelling of the ankles or feet, yellowing of the eyes or skin, dark urine. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: blood disorders, diabetes, high blood pressure, liver disease, kidney disease, bone disease, allergies (especially drug allergies). Birth control measures are recommended during therapy because this medication can cause fetal harm. Discuss with your doctor the risks related to pregnancy.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you use, including: calcium supplements and calcium-based antacids (including dairy products as well). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Laboratory tests will be done periodically to be sure the drug is working properly and to monitor for possible side effects.

Missed Dose

Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store in the refrigerator. Capsules may be left at room temperature between 59 and 86 degrees F (15 and 30 degrees C) for 24 to 48 hours if necessary.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).