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Ergotamine tartrate oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to treat migraine and cluster headaches.

How To Use

It is best to use this medication at the first sign of a headache. It will take longer to work if taken when the headache has already become severe. After using this, lie down in a quiet, dark room for an hour or two. Sublingual tablets are to be placed under the tongue to be dissolved. Do not swallow these tablets or eat or drink while it is dissolving. The aerosol spray should be shaken well before each dose. Rinsing your mouth out with water or gargling after taking a dose may help prevent hoarseness or throat irritation. Make sure you understand how often to use this medication and the maximum amount of medication that should be used. Do not exceed recommended dosage. Do not use daily on a regular basis. Review you dosing instructions with your doctor or pharmacist.

Side Effects

May cause dizziness, drowsiness, or stomach upset. These effects should disappear as your body adjusts to the medication. Notify your doctor if you experience: chest pain, irregular heartbeat, vomiting, muscle pain or numbness, pain or coldness in the hands or feet. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this drug, tell your doctor your medical history especially of: blood vessel problems, liver or kidney disease, severe itching, high blood pressure, circulation problems, drug allergies. Avoid activities requiring alertness if dizziness or drowsiness occurs. Avoid alcohol while taking this medication as it may make your headache worse. This medication must not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. This drug is excreted into breast milk and its use is not recommended while nursing. Consult your doctor before breast-feeding.

Drug Interactions

Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taken with drugs that affect liver metabolism (e.g., potent CYP 3A4 enzyme inhibitors). Do not take this medication with macrolide antibiotics (e.g., erythromycin, clarithromycin, troleandomycin), HIV protease inhibitors (e.g., retonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.g., ketoconazole, itraconazole). Tell your doctor of all prescription and nonprescription drugs you may use, especially of: beta-blockers (e.g., atenolol, propranolol), nitrates (e.g., isosorbide, nitroglycerin), nefazodone, fluconazole, fluoxetine, fluvoxamine, zileuton, clotrimazole, other mild CYP 3A4 enzyme inhibitors. Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor instructs you otherwise. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea; diarrhea; vomiting; numbness, tingling, and bluish discoloration of fingers and toes; drowsiness; and seizures.


Do not share this medication with others.

Missed Dose

If you miss a dose, do not double the next dose. Instead, skip the missed dose and resume your usual dosing schedule.


Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.