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Drotrecogin alfa (activated) intraven.
DROTRECOGIN ALFA - INJECTABLE

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

DROTRECOGIN ALFA - INJECTABLE

(droh-treh-KOH-gin)

COMMON BRAND NAME(S): Xigris

Uses

Drotrecogin alfa is a man-made (recombinant) form of a natural enzyme called Activated Protein C. It is used to treat severe/life-threatening infections in the blood (severe sepsis associated with acute organ failure).

How To Use

Follow all instructions for proper mixing and dilution with the correct IV fluids. If you have any questions regarding the use of this medication, consult your pharmacist. When mixing this drug, do not shake the vial(s). Gently swirl the mixture until all the powder has dissolved. Shaking this drug may cause it to become ineffective. Because of stability issues with this drug, each dose must be made immediately before it is given. Give this medication by vein (IV) continuously for 4 days (96 hours) mixed in a saline solution (NS). Each IV bag/bottle is given over 12 hours for a total of 8 bags/bottles; or give as directed by the doctor. The dosage is based on your weight, medical condition, and response to therapy. Before using, check this product visually for particles or discoloration. If either is present do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

No minor side effects are expected to occur. If any minor non-bleeding side effects occur, notify the doctor. Tell the doctor immediately if any of these unlikely but serious side effects occur: easy bruising or bleeding, bloody diarrhea, black stool, coffee-ground vomit, pink-colored/red urine, stomach/abdominal pain, one-sided weakness, vision problems, slurred speech, confusion. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact the doctor.

Precautions

This medication is not recommended for use if you have the following medical conditions: severe bleeding problems (e.g., internal bleeding, severe injury), conditions at risk for severe bleeding (e.g., recent stroke, recent head or spine surgery), brain disorders (e.g., aneurysm, tumors), currently have an epidural catheter. Tell your doctor your medical history, especially of: kidney disease, liver disease, HIV, organ transplants (especially of the bone marrow, lung, liver, pancreas, or small bowel), ulcers, low platelet counts, any allergies. This medication should be stopped 2 hours before having a surgical procedure and, if required, not restarted until 12 hours after the procedure. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: "blood thinners" (e.g., aspirin, heparin, warfarin, IIb/IIIa inhibitors), clot-dissolving drugs (e.g., thrombolytics such as alteplase, reteplase, urokinase). This drug may interfere with certain laboratory tests (e.g., activated partial thromboplastin times-aPTT). Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, stop the medication and contact your local poison control center or emergency room immediately. Symptoms of overdose may include: severe bleeding problems (see Side Effects section).

Notes

Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor your progress.

Missed Dose

If a dose is stopped or interrupted, contact the doctor to establish a new dosing schedule/rate.

Storage

Store unmixed/powder vials in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C) away from light. Do not freeze. Once mixed, the vials are good for 3 hours at room temperature (77 degrees F or 25 degrees C). Discard any unused portion of the vial(s). After mixing and subsequent dilution with IV fluids, this product must be used immediately and is stable at room temperature for 12 hours only.