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Doxylamine succinate and Pyridoxine HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(dox-ILL-uh-meen WITH pir-id-OX-een)


This medication contains doxylamine, an antihistamine, and pyridoxine, a form of vitamin B6. The combination is used to prevent or minimize nausea and vomiting associated with pregnancy.

How To Use

Take this medication by mouth as directed. Since most nausea and vomiting of pregnancy occurs in the morning, this medication is usually taken at bedtime. If nausea persists throughout the day, an additional dose midmorning or midafternoon may be necessary. Discuss your symptoms with your doctor and closely follow the prescribed dosing. Take this medication exactly as directed. Do not increase the dose, take it more often or continue taking this for longer than prescribed.

Side Effects

Drowsiness, dizziness, headache and irritability may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you experience: mental confusion, stomach pain, trouble sleeping. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: other illnesses, any allergies. Because this medication causes drowsiness, use caution driving or performing tasks requiring alertness while taking this drug. Limit alcohol intake while taking this medication. This medication should be used only if needed during pregnancy, usually the first few months. Discuss the risks and benefits with your doctor. Since small amounts of this medication appear in breast milk, consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription drugs you are taking, including: cough or cold preparations, antidepressants, narcotic pain relievers, tranquilizers. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe drowsiness, unsteadiness, severe dry mouth, trouble breathing, fainting, hallucinations, and seizures.


Do not share this medication with others.

Missed Dose

If you miss a dose, take it as soon as you remember. Do not take it if it is near the time for the next dose. Instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from heat, light and moisture. Do not store in the bathroom.