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Doxorubicin HCl liposomal intraven.
DOXORUBICIN W/LIPOSOMES

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

DOXORUBICIN W/LIPOSOMES

(dox-oh-REW-beh-sin WITH LIP-oh-sohmz)

COMMON BRAND NAME(S): Doxil

WARNING: This medication must be given slowly and directly into a vein (IV) after mixing with other intravenous fluids. Do not inject this medication into the muscle (IM) or just beneath the skin (SC). If this medication accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged. Notify the doctor immediately if redness, pain, and swelling occurs at, or around, the injection site. Doxorubicin may cause heart problems (including heart failure) or bone marrow suppression. Notify your doctor immediately if you develop an irregular heartbeat, trouble breathing, swelling of the hands or feet, easy bruising or bleeding, dry cough, or signs of infection such as fever, unusual fatigue, or persistent sore throat. Heart problems may occur during therapy or sometimes, months to years after receiving this medication. The risk of developing heart problems varies depending on your dose and condition. This medication may rarely cause severe, sometimes fatal allergic reactions during the infusion. See Side Effects section for details. Tell your doctor if you have liver problems since the dose should be decreased in this situation. Do not switch between different generics of this medication. They are not equal on a mg-per-mg basis. Your doctor will closely monitor you while you are using this medication.

Uses

This anticancer medication is used to treat AIDS-related Kaposi's sarcoma or cancer of the ovaries.

How To Use

This is administered by infusion into a vein over 30 minutes by a health care professional. It is usually given once every three weeks. The dose and frequency is based on your condition and response to previous therapy.

Side Effects

Nausea, vomiting, diarrhea, hair loss or irritation at the injection site may occur. If any of these effects persist or worsen, contact your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: mouth sores, unusual bruising or bleeding, unusual weakness, facial swelling, skin rash, peeling of the hands or feet. This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop any signs of an infection such as: fever, chills, persistent sore throat. This medication may rarely cause severe, even fatal allergic reactions during the infusion. Tell your doctor immediately if you develop any of these effects: headache, chills, flushing, swelling of the face, tightness in the chest or throat, back pain, trouble breathing, dizziness, fainting, unusually fast heartbeat. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Before using this, tell your doctor if you have: heart disease, liver disease, any allergies. Do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received oral polio vaccine. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports to lower the chance of getting cut, bruised or injured. This medication is not recommended for use during pregnancy. Consult your doctor before using this drug. It is not known if this drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any nonprescription or prescription medication you may use, especially of: digoxin, other anti-cancer drugs, progesterones, verapamil, cyclosporine, phenobarbital, phenytoin, streptozocin, live virus vaccines. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately.

Notes

Laboratory tests and blood counts will be done routinely while using this to monitor its effects and prevent side effects.

Missed Dose

It is important that each dose be used as scheduled. If you miss a dose, contact your doctor who will help establish a new dose schedule. Do not "double-up" the dose to catch up.

Storage

Store this in the refrigerator at 36 to 46 degrees F (2 to 8 degrees C) as directed. Once prepared the diluted solution may be refrigerated and should be used within 24 hours. May be frozen if used within one month. Check the expiration date on the label and properly discard of any unused medication after that time.