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Donepezil HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to treat Alzheimer's disease.

How To Use

Take this medication orally. It is usually taken once daily just before bedtime. This medication may be taken with or without food. If you experience sleeping problems (e.g., insomnia), consult your doctor about switching to morning dosing. It may take a few weeks before the full effects of donepezil are noticed. Take donepezil exactly as directed. Do not stop taking it or increase the dosage unless your doctor instructs you to do so.

Side Effects

Donepezil may cause nausea, diarrhea, vomiting, insomnia, muscle cramps, unusual tiredness or loss of appetite. If these effects continue or worsen, contact your doctor. Unlikely but report: headache, dizziness or fainting, weight loss, vision problems, chest pain, joint pain, depression, unusual dreams, drowsiness, new mental changes, rash, stomach pain, frequent urination, unsteadiness. Very unlikely but report: slow or irregular heartbeat, slurred speech, seizures, black stools. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: seizures, liver disease, heart problems, stomach or intestinal problems, lung disease, allergies (especially drug allergies). Because of the possibility this drug will make you dizzy and affect coordination, do not drive or operate machinery until you get used to the drug's effects. Limit or avoid alcohol intake as it may increase the possibility you will get dizzy or sleepy. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if donepezil is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Before taking this medication tell your doctor of all prescription and nonprescription medications you are taking especially of: anticholinergics (e.g., atropine, scopolamine, benztropine, diphenhydramine), succinylcholine, neostigmine, bethanechol. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include severe nausea, vomiting, sweating, slow pulse, dizziness, lightheadedness, slow breathing, and seizures.


Do not share this medication with others.

Missed Dose

Take any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not "double-up" the dose.


Store at room temperature between 59 to 86 degrees F (15 to 30 degrees C). Keep away from moisture and sunlight. Do not store in the bathroom.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).