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Dolasetron mesylate oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Dolasetron is used to prevent or treat nausea and vomiting due to anti-cancer therapy or surgery. It works by blocking the hormone (serotonin) that causes vomiting.

How To Use

This drug is taken by mouth, generally within one hour before certain cancer chemotherapy or within two hours before surgery. The maximum dose is 100mg.

Side Effects

Headache or dizziness may occur. If these effects persist or worsen, notify your doctor promptly. Unlikely but report promptly: chest pain, chills, unusual change in amount of urine. Very unlikely but report promptly: rash, stomach pain, unusual bleeding or bruising. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, fast/irregular heartbeat. In the unlikely event you have an allergic reaction to this drug seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), heart problems, low mineral levels (electrolyte imbalances such as low potassium or magnesium). Since this drug may cause dizziness, caution is advised when performing hazardous tasks (e.g., driving). Limit alcohol intake, since it may aggravate drug side effects. Tell your doctor if you are pregnant before using this medication. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all nonprescription and prescription medication you may use, especially of: diuretics (water pills), anthracycline cancer drugs (e.g., doxorubicin, idarubicin), cimetidine, rifamycins (e.g., rifampin), phenytoin, carbamazepine. Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, quinidine, sotalol, procainamide, sparfloxacin. Ask your doctor or pharmacist for more details. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with others.

Missed Dose

If the dose is missed, contact your doctor immediately.


Store at room temperature between 68 and 77 degrees F (20-25 degrees C) away from light and moisture.