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Dolasetron mesylate intraven.

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Dolasetron is used to prevent or treat nausea and vomiting due to anti-cancer therapy or surgery. It works by blocking the hormone (serotonin) that causes vomiting.



This medication may also be used to prevent nausea and vomiting due to radiation therapy.

How To Use

This drug is given by vein (IV), generally as a single dose 30 minutes before certain cancer chemotherapy, or during/after surgery. This liquid product may be mixed in apple or apple-grape juice for use in children, given one hour before cancer chemotherapy or within 2 hours before surgery. This drug product should be checked visually for particles or discoloration before use. If present, do not use the liquid. Containers of this product are for single use only.

Side Effects

Headache or dizziness may occur. If these effects persist or worsen, notify your doctor promptly. You may experience redness, irritation or swelling at the injection site. If this continues or worsens, contact your doctor. Unlikely but report promptly: chest pain, chills, unusual change in amount of urine. Very unlikely but report promptly: rash, stomach pain, unusual bleeding or bruising. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular heartbeat. In the unlikely event you have an allergic reaction to this drug seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), heart problems, low mineral levels (electrolyte imbalances such as low potassium or magnesium). Since this drug may cause dizziness, caution is advised when performing hazardous tasks (e.g., driving). Limit alcohol intake, since it may aggravate drug side effects. Tell your doctor if you are pregnant before using this medication. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all nonprescription and prescription medication you may use, especially of: diuretics (water pills), anthracycline cancer drugs (e.g., doxorubicin, idarubicin), cimetidine, rifamycins (e.g., rifampin), phenytoin, carbamazepine. Report other drugs which affect the heart rhythm (QTc prolongation), such as: dofetilide, pimozide, quinidine, sotalol, procainamide, sparfloxacin. Ask your doctor or pharmacist for more details. This product should not be mixed with other drugs in the same syringe or same liquid. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with others.

Missed Dose

If the dose is missed, contact your doctor immediately.


Store the vial or ampule at room temperature between 68 and 77 degrees F (20-25 degrees C) away from light and moisture. If diluted with compatible IV fluids (consult your pharmacist for details), this product is stable at room temperature for 24 hours or refrigerated for 48 hours. If diluted with juice, the mixture may be kept up to 2 hours at room temperature before use.