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Diflunisal oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication relieves pain and reduces inflammation. It is commonly used to treat pain, swelling and stiffness associated with arthritis.

How To Use

Take with food or immediately after meals to prevent stomach upset. These tablets must be swallowed whole. Do not crush or chew them. For arthritis, it may take one to two weeks before the full effects of this medicine are noted. For best results in arthritis, this must be taken regularly, as directed by your doctor.

Side Effects

Stomach upset, dizziness and drowsiness may occur. If these effects persist or worsen, notify your doctor promptly. Inform your doctor if you develop: black or bloody stools, edema (swelling of the feet or hands), vision changes. Report these rarely occurring side effects promptly: ringing in the ears, hearing loss, dark urine, yellowing of the eyes or skin, easy bruising. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: bleeding problems, liver problems, kidney problems, heart disease, high blood pressure, asthma, ulcers or other stomach problems, allergies (especially drug allergies). This medicine may cause stomach bleeding. Daily use of alcohol, especially when combined with this medicine, may increase your risk for stomach bleeding. Check with your doctor or pharmacist for more information. This medication is not recommended for use in children below 12 years of age. Diflunisal should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Diflunisal is excreted into breast milk. Though to date there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all over-the-counter and prescription medications you use, especially of: "blood thinners" (anticoagulants and antiplatelet drugs such as warfarin, heparins, other NSAIDs), antacids (regular use), cyclosporine, hydrochlorothiazide (a "water pill"), methotrexate. Do not take acetaminophen, NSAID (e.g., ibuprofen) or aspirin without first consulting your doctor or pharmacist. Check the labels of all your medications carefully. Ask your pharmacist if you are uncertain your other medicines contain these drugs. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, diarrhea, drowsiness, confusion, ringing in the ears, rapid pulse, rapid breathing, sweating, stupor, and coma.


Do not share this medication with others.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature away from sunlight and moisture.