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Difenoxin HCl and Atropine sulfate oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(dye-fen-OX-in WITH AT-trow-peen)



This medication is used to relieve diarrhea.

How To Use

Take this medication as prescribed. Do not increase your dose or take it more often than prescribed. If diarrhea is not relieved in a few days, notify your doctor.

Side Effects

Dizziness, drowsiness, dry mouth, or nausea may occur as your body adjusts to the medication. Inform your doctor if you experience any of these effects while taking this medication: abdominal pain, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.


Alcoholic beverages may increase the drowsiness caused by atropine and difenoxin. Atropine and difenoxin can affect certain medical conditions. Tell your doctor if you have: alcoholism, chronic lung disease, colitis, liver disease (including cirrhosis and jaundice). Before surgery, including dental surgery, tell the doctor that you are taking this drug. Difenoxin can be habit-forming. Stopping the medication suddenly after taking high doses or after taking it over a long time may cause withdrawal. Symptoms of withdrawal include: muscle and stomach cramps, unusual sweating, nausea and vomiting, shaking or trembling. Women who are pregnant or breast-feeding should inform their doctors. Difenoxin may pass from a mother to her baby through the milk and atropine is excreted in breast milk. Do not allow anyone else to take this medication.

Drug Interactions

Before taking atropine and difenoxin, tell your doctor of any over-the-counter or prescription drugs you take especially: MAO inhibitors (e.g., furazolidone, linezolid, phenelzine, selegiline, tranylcypromine), narcotic cough or pain relievers, sleeping pills, tranquilizers, muscle relaxants. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include initially rapid heartbeat, followed by sluggishness, coma, pinpoint pupils, and slowed breathing.


Do not share this product with others.

Missed Dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom.