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Demeclocycline HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Demeclocycline is an antibiotic used to treat a wide variety of bacterial infections. It is also used to treat acne and to prevent "traveler's diarrhea".



This drug may also be used for special cases of fluid retention (SIADH).

How To Use

This medication works best if taken on an empty stomach one hour before or two hours after meals. Take each dose with a full glass of water (4oz. or 120ml) or more. Do not lie down for 30 minutes after taking this drug. It may be taken with food if stomach upset occurs unless your doctor directs you otherwise. Take this medication 2-3 hours before or after taking any products containing magnesium, aluminum, or calcium. Some examples include quinapril, didanosine, vitamins/minerals, and antacids. Dairy products (e.g., milk, yogurt), calcium-enriched juice, sucralfate, bismuth subsalicylate, iron, and zinc are also included. These products bind with demeclocycline preventing its full absorption. This medication works best when the amount of medicine in your body is kept at a constant level. Do this by taking the medication at evenly spaced intervals throughout the day and night. When using this for an infection, continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a relapse of the infection. If you are using this for fluid retention due to SIADH, take it exactly as directed by your doctor.

Side Effects

This medication may cause stomach upset, diarrhea, nausea, headache or vomiting. If these symptoms persist or worsen, notify your doctor. Very unlikely but report promptly: stomach pain, yellowing eyes or skin, vision changes, mental changes, increased urination. This medication may increase sensitivity to sunlight. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney or liver problems, diabetes insipidus, trouble swallowing or esophagus problems (e.g., hiatal hernia, GERD), any allergies you may have. Use of this medication for prolonged or repeated periods may result in a secondary infection (e.g., oral, bladder or vaginal yeast infection) or sore throat while taking this medication. This medication may make you more prone to sunburn. Wear protective clothing and a sunscreen if needed. This drug should not be used by children up to 8 years of age because its use may permanently discolor their teeth or cause other problems. Caution is advised in older children also. This drug is not recommended for use during pregnancy. Consult your doctor before using this medication. This drug is excreted into breast milk and has been shown to have undesirable effects on nursing infants. Therefore, its use is not recommended while breast-feeding. Consult your doctor before you breast-feed.

Drug Interactions

Inform your doctor or pharmacist about all the medicines you may use (both prescription and nonprescription), especially of: vitamins/minerals (e.g., magnesium, aluminum, calcium, iron, zinc), quinapril, didanosine, antacids, sucralfate, bismuth subsalicylate, digoxin, penicillin-related drugs, live vaccines, cimetidine, warfarin, methoxyflurane. This medicine may decrease the effectiveness of oral contraceptives. Consult your doctor or pharmacist about other types of birth control. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


This medication has been prescribed for your current condition only. Do not use it later for another infection or give it to someone else. A different medication may be necessary.

Missed Dose

If you should miss a dose, take it as soon as remembered unless it is almost time for the next dose. If it is nearly time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose.


Store at room temperature away from moisture and sunlight. Do not store in the bathroom. Discard any unused drug. Check the drug's expiration date. Taking outdated demeclocycline can result in serious illness.