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Delavirdine mesylate oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: Didanosine-delavirdine combination treatment is not recommended because delavirdine did not add to the benefit of didanosine in a clinical test. The HIV virus quickly develops resistance when delavirdine is used alone. Therefore, delavirdine must always be used with other proven combinations of anti-HIV medications.


This medication is used in the treatment of infection with HIV (the virus that causes AIDS). It is used in combination with other HIV medications (antiretrovirals) in selected patients. No cure exists for HIV infection, and the illnesses associated with your disease (infections, etc.) may continue.

How To Use

Take by mouth exactly as directed, usually three times a day with or without food. Delavirdine 200 mg tablets cannot be dissolved in a glass of water before swallowing, unlike the 100 mg tablets. Swallow these tablets whole. If taking didanosine or antacids, take them one hour apart from this drug. For anyone with lack of stomach acid (achlorhydria), take this drug with an acidic beverage (e.g., orange or cranberry juice).

Side Effects

Headache or nausea might occur. If these persist or worsen, notify your doctor. Report to your doctor promptly: rash, itching. Unlikely but report promptly: vomiting, stomach pain, yellowing skin or eyes, fever, trouble breathing, swelling, dizziness/fainting, persistent sore throat, unusual bleeding or bruising. If you notice other effects not listed above, contact your doctor or pharmacist.


Before taking this drug, tell your doctor your entire medical history, including: allergies (particularly drug allergies), liver disease. Report promptly to your doctor: severe rash, rash with symptoms (e.g., fever, blistering, mouth sores, swelling, muscle/joint aches). This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into human milk. Avoid breast-feeding to prevent transmission of HIV infection to an uninfected infant. Caution is advised when using this drug in children under 16 years of age.

Drug Interactions

This drug is not recommended for use with: rifabutin, rifampin. Ask your doctor or pharmacist for more details. Tell your doctor of all nonprescription and prescription medication you may take, especially: antacids (containing aluminum and magnesium), clarithromycin, didanosine, fluoxetine, ketoconazole, phenytoin, phenobarbital, carbamazepine, terfenadine, astemizole, dapsone, ergot derivatives (e.g., cafergot, ergotamine), alprazolam, midazolam, triazolam, nifedipine-like calcium channel blockers, cisapride, quinidine, warfarin, amphetamines, H2 blockers (e.g., cimetidine), St John's wort, sildenafil, protease inhibitors (e.g., amprenavir). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with anyone else. This medication has not been shown to reduce the chance of transmitting HIV to others.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 68 and 77 degrees F (20-25 degrees C) away from light and moisture. Keep container tightly closed.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).