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Cytarabine liposome intrathec.

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: In clinical studies, this medication has caused a serious, sometimes fatal, condition called arachnoiditis. This condition is treatable. Therefore, cytarabine liposome must only be given in a health-care facility (e.g., clinic, hospital) under close monitoring by a doctor experienced in cancer chemotherapy. Tell your doctor immediately if these side effects occur: nausea, vomiting, headache, fever, neck pain or stiffness, or back pain. These symptoms may be related to arachnoiditis or side effects of the drug. Consult your doctor for details.


Cytarabine liposome is a long-acting (sustained-release) chemotherapy drug used to treat a certain type of cancer affecting the area around the spinal cord (lymphomatous meningitis).

How To Use

Use extreme caution when handling and/or mixing this medication. As with other cancer chemotherapy drugs, this medication may be harmful if it comes in contact with healthy cells (e.g., skin, muscle). After mixing with the correct IV fluids (preservative-free diluent), this medication will contain small particles (suspension). Avoid aggressive shaking of this drug and do not filter this drug. Doing so may make this medicine ineffective. Your doctor will inject this medication directly into the spinal fluid (CSF) over 1 to 5 minutes usually every 14 days or as directed. The dosage and length of treatment depends on your medical condition and response to therapy. After several months, your doctor may only give this drug every 28 days (maintenance dose). After receiving this medication, you will be instructed to lie flat for 1 hour. Other medication(s) such as dexamethasone will be given before, and for several days following your treatment with this drug to reduce the risk of serious side effects. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Nausea, vomiting, or fever may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: headache, tingling or numbness, back pain, neck pain or stiffness, swelling. Tell your doctor immediately if any of these unlikely but serious side effects occur: unusual weakness/fatigue, easy bruising or bleeding, persistent sore throat, mental/mood changes, seizures. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication is not recommended for use if you have the following medical conditions: bacterial or viral meningitis. Tell your doctor your medical history, especially of: any allergies. Because this medication can decrease your immune system function, do not have immunizations/vaccinations without the consent of your doctor and avoid contact with people who have recently received live vaccines (e.g., oral polio vaccine. Use caution with sharp objects like safety razors or nail cutters and avoid activities that may increase the chance of getting cut, bruised, or injured. This medication is not recommended for use during pregnancy. Consult your doctor for more details. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: digoxin, other cancer chemotherapy drugs. This product may affect the results of certain lab tests (e.g., white blood cell counts in CSF). Make sure laboratory personnel and your doctors know that you are being treated with this drug. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: severe headache/pain, loss of consciousness.


Laboratory and/or medical tests (e.g., blood tests) may be performed to monitor your progress and for side effects.

Missed Dose

If you miss a dose or your dosing schedule is interrupted, contact your doctor promptly to establish a new dosing schedule.


Before mixing, store the unmixed vial/powder in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Avoid aggressive shaking of the vial(s). Once mixed, use this drug immediately. Discard any unused portion of the vial.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).