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Cosyntropin injection

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Cosyntropin is a man-made (synthetic) portion of the natural hormone ACTH. It is used to help doctors diagnose adrenal gland problems (e.g., Addison's disease, insufficiency due to steroid use, tumors).



This drug may also be used for long-term (chronic) medical conditions that produce swelling (inflammation) that may respond to corticosteroids.

How To Use

This medication is injected into a muscle (IM) or into a vein (IV). When given IV, it may be injected directly into the vein over 2 minutes or infused over 6 hours mixed in a dextrose or saline solution as directed by your doctor. Depending on the type of test your doctor is performing, he/she may require blood or urine samples to measure your response to the test(s). Consult your doctor for details. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Minor irritation at the injection site (e.g., redness, swelling) may occur. If any of these effects persist or worsen, notify your doctor. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: severe swelling, irregular heartbeat, headache, dizziness, blurred vision. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney problems, any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: "water pills" (diuretics such as furosemide, hydrochlorothiazide), mifepristone. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Laboratory and/or medical tests may be performed to monitor your progress.

Missed Dose

Not applicable.


Before mixing, store at room temperature between 59 and 86 degrees F (15 and 30 degrees C) away from light. After mixing, this product should be used immediately. Discard any unused portion of the vial.