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Colistimethate sodium injection

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Colistimethate is an antibiotic used to treat a wide variety of serious bacterial infections (e.g., gram negative infections such as Pseudomonas or Klebsiella).

How To Use

Follow all instructions for the proper mixing, dilution with the correct IV fluids, and dosing schedule. If you have any questions regarding the use of this medication, consult your pharmacist. Once the mixing solution has been added to the vial, gently swirl or roll the vial back and forth between your hands. Do not shake the vial. Before using, check this product visually for any unusual particles or discoloration. If either is present, do not use the liquid. Inject this medication into a vein (IV) or into a muscle (IM) as directed by your doctor. The dosage and length of treatment is based on your weight, medical condition, and response to therapy. Do not mix this medication to be used at a later time. Only use freshly mixed vials and/or IV solutions. Antibiotics work best when the amount of medicine in your body is kept at a constant level. Therefore, give this drug at evenly spaced intervals. Continue to use this medication until the fully-prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Nausea/vomiting, itching, and rash may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: tingling or numbness in the arms/legs or tongue, slurred speech, dizziness, fever, lightheadedness, trouble breathing, change (decrease) in amount of urine, diarrhea. Use of this medication for prolonged or repeated periods may result in a secondary infection (e.g., oral or vaginal fungal infection). Contact your doctor if you notice white patches in your mouth, a change in vaginal discharge, or other new symptoms. If you notice any other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney problems, any allergies. This drug may make you dizzy or drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Based on information for similar drugs, this medication may pass into breast milk. Therefore, consult your doctor before breast-feeding.

Drug Interactions

This drug is not recommended for use with aminoglycoside antibiotics (e.g., gentamicin, tobramycin), polymyxin, or sodium cephalothin. Using this medication with these products may cause serious nerve side effects or kidney problems. Ask your doctor or pharmacist for more details. Tell your doctor of all prescription and nonprescription medication you may use, especially: certain muscle relaxants (e.g., curare-like drugs such as decamethonium, ether, gallamine, sodium citrate, succinylcholine, or tubocurarine), live vaccines (e.g., oral polio vaccine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: loss of coordination, uncontrolled eye movements (nystagmus), confusion, severe trouble breathing.


This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases. Do not share this medication with others. Laboratory and/or medical tests (e.g., creatinine, BUN) will be performed to monitor your progress.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store the unmixed/powder vials at room temperature between 59 and 86 degrees F (15 to 30 degrees C). Do not freeze. Once mixed, the suspension is good for 7 days and should be refrigerated between 36 and 46 degrees F (2 to 8 degrees C). After mixing and subsequent dilution with IV fluids, this product is stable at room temperature or refrigerated (below 77 degrees F or 25 degrees C) for 24 hours.