Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00
Chlorambucil oral
CHLORAMBUCIL - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

CHLORAMBUCIL - ORAL

(klor-AM-byou-sill)

COMMON BRAND NAME(S): Leukeran

WARNING: Chlorambucil can cause cancer or weaken your bone marrow. Bone marrow is where blood cells are made that protect you against infections/illness. Notify your doctor immediately if you develop signs of infection (persistent sore throat or fever), easy bruising or bleeding, or unusual fatigue. Chlorambucil may damage chromosomes (genes); has left men and women sterile (inability to have children); and has caused birth defects.

Uses

Chlorambucil is one of a group of drugs known as alkylating agents"; these drugs are also known as cancer drugs, chemotherapy, antineoplastics or "chemo". They are used in the treatment of various cancers to slow or stop the growth of cancer cells. A combination of different types of cancer drugs will often be used to achieve better results and minimize side effects.

How To Use

This is a potent medication. Take it exactly as prescribed. Unless your doctor instructs you otherwise, drink plenty of fluids while taking this medication. This helps your kidneys to remove the drug from your body and avoid some of the side effects. Do not stop taking this medication, even if you feel nauseated or experience vomiting. If you vomit shortly after a dose, or if you miss a dose, contact your doctor.

Side Effects

Nausea, vomiting, or changes in menstrual period are common side effects. Taking the medication on an empty stomach with a full glass of water may help relieve vomiting. Changes in diet such as eating several small meals or limited activity may help lessen some of these effects. In some cases, drug therapy may be necessary to prevent or relieve nausea and vomiting. Contact your doctor, without delay, if you experience any of the following symptoms: fever, chills, painful or difficult urination, easy bruising or bleeding, black, tarry stools, blood in urine or stools, small red spots on the skin, joint pain, swollen feet or lower legs, sores in mouth or on lips, yellow eyes or skin, cough, lower back or side pain, stomach pain, trouble walking, muscle twitching, agitation, confusion, hallucinations, weakness, paralysis. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

This medication can lower your body's ability to fight an infection. Notify your doctor if you develop any signs of an infection such as fever, sore throat, rash, or chills. Do not have immunizations/vaccinations without consent of your doctor, and avoid contact with people who have recently received oral polio vaccine. Contraceptive (birth control) measures are recommended for use in men and women while taking this medication. This medication is not recommended for use during pregnancy. Consult your doctor for details. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding. Tell your doctor if you have: gout, kidney stones, seizures, head injury, allergies (especially drug allergies).

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include agitation, dizziness, and seizures.

Notes

Avoid touching your eyes or inside your nose without first washing your hands. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports in order to lower the chance of getting cut, bruised or injured. Regular doctor visits are important. Frequent blood tests will be done to monitor therapy.

Missed Dose

Do not double dose if missed. Contact your doctor.

Storage

Store in refrigerator (2 to 8 degrees C) 36 to 46 degrees F.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).