Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00
Chloral hydrate rectal

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(KLOR-ull HI-drate)



This medication is used as a sleeping aid to improve sleep disturbances.

How To Use

This is best used 15 to 30 minutes before bedtime. If the suppository is too soft, refrigerate for 30 minutes or run under cold water before removing the foil wrap. Unwrap and moisten the suppository slightly with water. Lie down on your left side with the right knee bent (or the reverse if left handed). Push the suppository well into the rectum with your finger. Remain lying down for 2-3 minutes so the medication gets absorbed properly.

Side Effects

This medication causes drowsiness and dizziness. Avoid tasks requiring alertness. You may experience headache, stomach upset, dizziness or an unpleasant taste in the mouth during the first few days as your body adjusts to the medication. If these effects persist or become bothersome, inform your doctor. Notify your doctor if you develop: confusion, nightmares, loss of coordination, fainting, breathing difficulties, skin rash, itching, yellowing of the eyes or skin. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: heart problems, liver disease, kidney disease, allergies (especially drug allergies). Elderly persons are usually more sensitive to the effects of this medication. Use cautiously. This medication is not recommended for use during pregnancy. Discuss the risks and benefits with your doctor. Since this medication may appear in breast milk, consult with your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription drugs you may use, especially of: "blood thinners" (e.g., warfarin), other sleep aids, drowsiness-causing antihistamines (e.g., diphenhydramine), narcotic pain relievers (e.g., codeine), tranquilizers, muscle relaxants, antidepressants, anti-anxiety drugs, anti-seizure drugs, phenothiazines (e.g., chlorpromazine, prochlorperazine), other drugs that make you drowsy. Check the labels on all your medicines (e.g., cough-and- cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. Limit alcohol consumption. If you are a diabetic, use TesTape or Clinistix to test your urine for sugar. Do not use Clinitest because chloral hydrate can cause false results. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include decreased pupil size, slow or fast and shallow breathing, and vomiting.


Use exactly as prescribed. Do not increase your dose or use this more often than prescribed. Tolerance may develop to this medication making it less effective with prolonged use. Do not stop using this medication without your doctor's approval. Your dose may have to be gradually decreased if you have been using it for some time. Do not allow anyone else to use this medication.

Missed Dose

If you miss a dose, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) unless otherwise directed by the manufacturer. Keep away from moisture and sunlight. Do not store in the bathroom.