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Cevimeline HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to treat the symptom of dry mouth in patients with Sjogren's Syndrome. Cevimeline increases the activity of glands in the mouth and skin (e.g., salivary and sweat glands).



This medication may also be used for dry mouth symptoms due to other causes.

How To Use

This medication is taken by mouth, usually three times a day. It may be taken with or without food but is best absorbed on an empty stomach. If unusual sweating occurs while taking this medication, drink extra water throughout the day and consult your doctor or pharmacist.

Side Effects

Nausea, vomiting, diarrhea, excessive sweating, rash, headache, runny nose, cough, drowsiness, hot flashes, blurred vision, or trouble sleeping may occur. If these effects persist or worsen, notify your doctor. Tell your doctor immediately if you have any of these serious side effects: trouble breathing, fever, sore throat, painful or frequent urination, unusual joint or muscle pain. Tell your doctor immediately if you have any of these unlikely but serious side effects: chest pain, irregular heartbeat, easy bruising or bleeding, yellowing eyes or skin, stomach pain, mental/mood changes. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, including: allergies, liver or heart disease, breathing problems (e.g., asthma, bronchitis, COPD), eye problems (e.g., glaucoma, acute iritis), kidney stones, gall bladder problems (gall stones). This drug may make you dizzy or cause vision problems; use caution engaging in activities requiring alertness such as driving or using machinery especially at night or in poor light. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you use, especially of: beta-blockers (e.g., propranolol, metoprolol), SSRI antidepressants (e.g., fluoxetine, paroxetine,), amiodarone, quinidine, indinavir, haloperidol, terbinafine, ticlopidine. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include irregular heartbeat, severe diarrhea, nausea, sweating, vision changes.


Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor your progress.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15 to 30 degrees C) is permitted.