Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00
Carbidopa and Levodopa oral
LEVODOPA WITH CARBIDOPA - ORAL SUSTAINED RELEASE

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

LEVODOPA WITH CARBIDOPA - ORAL SUSTAINED RELEASE

(lee-voh-DOE-puh WITH kar-beh-DOE-puh)

COMMON BRAND NAME(S): Sinemet CR

Uses

This medication is used to treat symptoms of Parkinson's disease. Carbidopa is used to make levodopa more effective. Carbidopa has no effect when given alone.

How To Use

Take this drug as directed. It may take a few weeks before the full benefits of this medication are observed. If you are changing from plain levodopa to this drug, levodopa must be discontinued for 8 hours before taking this combination drug. If stomach upset occurs, this drug may be taken with food or milk. Consult with your doctor. Do not crush or chew the tablets. The 50/200mg strength tablets may be broken in half. Do not break the 25/100mg strength tablets in half; doing so will change the drug's release system and may increase the possiblity of side effects.

Side Effects

May cause drowsiness, dizziness, headache, loss of appetite, stomach upset, nausea, vision changes, or trembling of the hands. These should subside as your body adjusts to the medication. If these symptoms persist or become bothersome, inform your doctor. Notify your doctor if you develop any of these serious effects while taking this medication: vomiting, difficulty swallowing, difficulty urinating, uncontrollable movements (especially twitching of the eyelid), chest pain, irregular heartbeat, skin rash, mental/mood changes. May cause darkening of the urine or sweat. This is not harmful and will disappear when the medication is stopped. May cause dizziness especially when rising quickly from a seated or lying position. Change positions slowly and be careful on stairs. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

This medication can cause false results in urine glucose testing in diabetes. TesTape should be used to test urine for accurate results. Tell your doctor your medical history, especially of: glaucoma, skin cancer, breathing problems, heart disease, gland problems e. g., diabetes, thyroid), kidney or liver disease, ulcers, depression, blood disorders. This drug should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. Levodopa appears in breast milk. Do not take this medication if you are breast-feeding.

Drug Interactions

Tell your doctor of all the medications you may use, (both prescription and nonprescription), especially of: MAO inhibitors (e.g., furazolidone, moclobemide, phenelzine, procarbazine, selegiline, tranylcypromine), drugs used for depression or anxiety, iron vitamins, phenytoin, blood pressure drugs, pyridoxine, any other drugs used for Parkinson's disease. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include irregular heartbeat and muscle spasms.

Notes

Be sure your doctor knows your complete medical history and the medications you are taking.

Missed Dose

If you miss a dose, take as soon as remembered and take any remaining dose for that day at evenly spaced intervals. Do not "double-up" the dose to catch up.

Storage

Store at room temperature away from sunlight and moisture. Do not store in the bathroom.