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Captopril and Hydrochlorothiazide oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(KAP-toe-pril WITH THIGH-uh-zide)


WARNING: This drug can cause serious fetal harm if used during the last six months of pregnancy. If pregnancy occurs, stop using this drug and immediately contact your physician.


Captopril prevents certain enzymes in the body from narrowing blood vessels. This helps to lower blood pressure and makes the heart beat stronger. Thiazides are "water pills" (diuretics) that help reduce blood pressure. This medication is used to treat high blood pressure.

How To Use

This medication should be taken on an empty stomach, one hour before or two hours after a meal. Take this medication exactly as prescribed. Try to take it at the same time each day. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased. Consult your doctor before using salt substitutes or low salt milk. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Side Effects

Dizziness, headache, diarrhea, constipation, loss of appetite, nausea, loss of taste, flushing, fatigue, cough or increased urination may occur. If these effects persist or worsen, notify your doctor. This medication can increase sensitivity to sunlight. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. Inform your doctor if you develop: chest pain, tingling of the hands or feet, persistent sore throat. This drug may rarely cause serious (possibly fatal) liver problems. If you notice any of the following highly unlikely but very serious side effects, seek immediate medical attention: yellowing of the eyes or skin, dark urine, stomach/abdominal pain, persistent fatigue, persistent nausea. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: liver, kidney or heart problems, urinary problems, diabetes, allergies (especially allergies to sulfa drugs). The hydrochlorothiazide in this product may increase your sensitivity to sunlight. Avoid prolonged sun exposure. If you become sun sensitive, use a sunscreen and wear protective clothing when outdoors. Limit your intake of alcohol and use caution when exercising and during hot weather because these factors may increase the risk of dizziness. This medication should be used only when clearly needed during the first three months of pregnancy. It is not recommended for use during the last six months of the pregnancy. Discuss the risks and benefits with your doctor. This drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

This drug is not recommended for use with: dofetilide. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicine you use (both prescription and nonprescription) especially of: lithium, potassium supplements, potassium-sparing water pills, anti- inflammatory drugs (e.g., ibuprofen), digoxin. Avoid drugs that may increase your heart rate such as decongestants or caffeine. Decongestants are commonly found in cough-and-cold medicines. Read drug labels carefully. If you are uncertain your drug products increase heart rate, ask your doctor or pharmacist. If you take colestipol or cholestyramine, take this medicine 1 hour before or 4 hours after the cholesterol-lowering medicine so they do not decrease the absorption of this drug. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include dizziness, fainting, and weakness.


It is important to have your blood pressure checked regularly while taking this medication. Learn how to monitor your blood pressure. Discuss this with your doctor.

Missed Dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature away from sunlight and moisture.