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Ziprasidone HCl oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Ziprasidone is used to treat schizophrenia.

How To Use

Review the Patient Information Leaflet. Ask your doctor or pharmacist any questions you may have. Take this medication by mouth usually twice daily with food; or take as directed by your doctor. Do not take this medication more often or increase your dose without consulting your doctor. Your condition will not improve any faster and the risk of serious side effects may be increased. Do not stop taking this drug without your doctor's approval.

Side Effects

Drowsiness, dizziness, nausea, constipation, or weight gain may occur. If these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these unlikely but serious side effects occur: muscle stiffness, muscle spasms or twitching, unusual decrease in amount of urine, change in vision. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: fainting, irregular or unusually fast heartbeat (especially with fever and increased sweating), seizures, trouble swallowing, uncontrolled movements (especially of the face or tongue). Males: In the unlikely event you experience a painful or prolonged erection, seek immediate medical attention as this is considered a medical emergency. This medication may in rare instances increase your blood level of a certain hormone (prolactin). In females, this rare increase in prolactin levels may result in unwanted breast milk production, stopping of your menstrual period, or difficulty in becoming pregnant. In males, this rare effect may result in decreased sexual ability, inability to produce sperm, or enlarged breasts. If you develop any of these symptoms, tell your doctor immediately. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: heart problems (e.g., QTc prolongation, arrhythmias, recent heart attack, heart failure). Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver problems, electrolyte imbalance (e.g., hypokalemia, hypomagnesemia), strokes (cerebrovascular disease), history of low blood pressure (e.g., dehydration, hypovolemia), seizures, swallowing difficulty, Alzheimer's disease, breast cancer, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug, especially the drowsiness and blood pressure-lowering effects. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended.

Drug Interactions

Other drugs besides ziprasidone which may affect the heart rhythm (QTc prolongation in the EKG) include dofetilide, pimozide, quinidine, sotalol, procainamide, and sparfloxacin among others. QTc prolongation can infrequently result in serious, rarely fatal, irregular heartbeats. Consult your doctor or pharmacist for details. Ask for instructions about whether you need to stop any other QTc-prolonging drugs you may be using in order to minimize the risk of this effect. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: anti-Parkinson drugs (e.g., pramipexole, ropinirole), azole antifungals (e.g., ketoconazole, itraconazole), certain blood pressure medications (e.g., beta-blockers such as metoprolol or propranolol, "water pills" or diuretics such as furosemide or hydrochlorothiazide, or alpha-blockers such as doxazosin or prazosin). Tell your doctor or pharmacist if you take drugs that cause drowsiness, including: anti-anxiety drugs (e.g., diazepam), antihistamines that cause drowsiness (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), other psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers. Check the labels on all your medicine (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of these products. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include slurring of speech, irregular or unusually fast heartbeat, or fainting.


Do not share this medication with others. Laboratory and/or medical tests (e.g., electrolytes) may be performed to monitor your progress. A manufacturer's Patient Information Leaflet about this medication should be dispensed with your prescription. Read the information carefully. Ask your doctor or pharmacist any questions you may have.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59-86 degrees F (15-30 degrees C) away from light and moisture. Keep all medicines away from children and pets.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).