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Urokinase injection

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: Internal bleeding may be more difficult to control with this medication than with other anticoagulant therapy. This medication must be used in a hospital setting. It should be started as soon as possible after lung blood clots have been noticed (pulmonary embolism), preferably within 7 days. Urokinase should be given within 6 hours of the first symptoms of a heart attack associated with evolving myocardial infarction.


This medication is a protein (enzyme) which works to break up and dissolve blood clots which can block arteries. It is used in the treatment of very serious blood clots in lung blood vessels (pulmonary embolism).

How To Use

This medication is given by injection by a health care professional. It is important this medication be used as prescribed. It is most effective when administered as soon as possible after symptoms appear (e.g., within 6 hours of onset of chest pain).

Side Effects

Dizziness, fever, headache, or nausea may occur shortly after the drug is given by vein (infusion reaction). Notify the doctor immediately if any of these effects occur, as the drug infusion may need to be stopped, or medication to treat the reaction may need to be given. Notify your doctor immediately if you experience: easy bruising or bleeding (e.g., pink urine, bleeding gums, black or bloody stools), a rapid or abnormal heartbeat, chest pain, tingling or numbness of the hands/feet. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. Rare (possibly fatal) cholesterol blood clots (emboli) may occur while using medicines that dissolve blood clots. Report immediately any of the following symptoms: change in amount of urine, severe stomach/abdominal pain, unexplained muscle pain, discolored toes or fingers. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: pre-existing bleeding disorders, high blood pressure, heart infection (endocarditis), recent biopsy or surgery, recent injury, any allergies. Use extra caution to avoid injury and trauma (e.g., carefully brushing teeth) while using this medication due to the increased risk of bleeding. Consult your doctor regarding the unlikely risk that this drug contains infectious material. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any prescription or nonprescription medication you may take including: "blood thinners" (e.g., warfarin), NSAIDs (e.g., ibuprofen, naproxen), aspirin. Drugs that can reverse effects of urokinase include: aminocaproic acid, aprotinin, tranexamic acid. Aspirin or NSAID drugs (e.g., ibuprofen) should not be used to treat fever, since they may increase the chance of bleeding while using urokinase. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Laboratory tests will be done frequently while using this medication to monitor its effects and to prevent side effects.

Missed Dose

Continued dosing is usually not necessary for this medication.


Store powder vial in refrigerator at 36-46 degrees F (2 to 8 degrees C). Reconstituted solution should be used immediately after reconstituting. Discard any unused portion.