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Trimethobenzamide HCl rectal

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to control nausea and vomiting.

How To Use

Unwrap the suppository and insert it gently but completely into the rectum, pointed-end first. Avoid excessive handling of the suppository so that it doesn't melt before use. This medication is usually used three to four times a day. Use it exactly as prescribed. Do not increase your dose or use this drug more often than directed.

Side Effects

Dizziness, drowsiness or headache may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: jaundice (e.g., yellowing of the eyes or skin, dark urine), blurred vision, mental confusion, muscle cramps, skin rash. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: high fever, stomach problems (gastroenteritis), swelling/disease of the brain (encephalitis/encephalopathy), mineral (electrolyte) imbalance, any allergies. Do not give children trimethobenzamide to treat vomiting when the cause of vomiting is unknown. Trimethobenzamide may worsen Reye's Syndrome, a rare but serious illness. Do not give trimethobenzamide (or aspirin or acetaminophen) to a child with symptoms of Reye's Syndrome (sudden, severe, persistent vomiting; drowsiness or stupor; unusual behavior; and seizures). Call the doctor immediately if these symptoms are present. Children and teenagers should not use this drug if they have chickenpox, influenza, or any undiagnosed illness without first consulting a doctor about Reye's syndrome. Use caution performing tasks requiring alertness if this medication makes you drowsy or dizzy. Limit alcohol intake because it will add to the dizziness or drowsiness effects of this medication. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medications you may use, especially of: narcotic pain medication (e.g., codeine), sleeping pills, tranquilizers, sedatives, barbiturates (e.g., phenobarbital), drowsiness-causing antihistamines (e.g., diphenhydramine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with others..

Missed Dose

If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store suppositories at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.