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Physostigmine sulfate ophthalmic

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(fye-so-STIG-meen, off-THAL-mick)


This medication reduces pressure in the eye. It is used to treat glaucoma.

How To Use

Wash hands first. Avoid touching the tip of the tube to any surface. Tilt head back and pull down lower eyelid to make a pouch. Place the tube as near as possible to the eyelid without touching it. Squeeze a 1/2 inch ribbon of ointment into the pouch of the eyelid. Blink your eyes a few times to allow dispersion of the medication over the eye surface. Wipe off any excess from the eyelids and eyelashes with tissue. Close lid tightly. Wash hands again to remove any ointment that may have come into contact with your hands.

Side Effects

Headache, brow ache, or temporary burning or stinging may occur initially. These effects should disappear as your body adjusts to the medication. Vision may be temporarily blurred or unstable after applying medication. Use caution if driving or performing duties requiring clear vision. This medication may cause vision problems in poor light. Use caution especially when driving at night. Crusting of ointment on eyelids or eyelashes may occur causing them to stick together. If this occurs, wash them with water. Notify your doctor if you develop: vision changes, eye pain, increased sweating, increased salivation, increased urination, nausea, vomiting, diarrhea, irregular heartbeat, difficulty breathing. Also, contact your doctor if blurred vision persists more than several hours in the morning after bedtime use. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: other eye problems, asthma, intestinal disease, ulcers, low or high blood pressure, heart disease, an overactive thyroid gland, seizures, Parkinson's disease, obstruction of the urinary tract, drug allergies. Before having surgery with a general anesthetic, tell the doctor or dentist that you use this medication. This drug should be used during pregnancy only if clearly needed. It is not known if this medication appears in breast milk. Consult with your doctor before breast-feeding.

Drug Interactions

This drug can affect the way your body responds to other drugs. Tell your doctor what prescription and nonprescription drugs you are taking. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed. Symptoms of overdose may include blurred vision, increased saliva, fainting, irregular heartbeat, nausea, vomiting, diarrhea, asthma, and increased sweating.


Do not share this medication with others.

Missed Dose

If you should miss a dose, apply as soon as remembered unless it is almost time for the next dose. In that case, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature away from heat and moisture.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).