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Nesiritide intraven.

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Nesiritide is used for the short-term treatment of an acute form of congestive heart failure (acute decompensated congestive heart failure-ADCHF). It is only to be used for people who have trouble breathing while doing little or no activity.

How To Use

Follow all instructions for proper mixing and dilution with the correct IV fluids. If you have any questions regarding the use of this medication, consult your pharmacist. Gently swirl or rock the vial after adding the mixing liquid. Do not shake the vial. Doing so could make the drug ineffective. Give this medication by vein (IV) as two separate injections (bolus followed by infusion); or as directed by your doctor. The dosage is based on your weight, medical condition, and response to therapy. After mixing the IV in a dextrose or saline solution, take out the correct amount of fluid to give as a single IV injection (bolus) over 1 minute. After giving the bolus dose, give the remaining IV solution over the recommended amount of time. Consult your pharmacist for details. Do not mix this medication with any other injectable medicine. Use a separate IV line for giving other injectable drugs. Your blood pressure should be monitored closely while using this medication. If you develop unusually low blood pressure, your treatment may need to be stopped or your dose reduced. Once the symptoms of acute heart failure are controlled, your treatment will be changed to different medication(s). Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Dizziness, lightheadedness, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: unusually fast or slow heartbeat, chest pain, back pain, stomach pain, vomiting, trouble sleeping, mental/mood changes. Tell your doctor immediately if any of these unlikely but serious side effects occur: fever, pain/swelling/redness of the injection site, tingling or numbness of the hands/feet, severe cough or coughing up blood, rash, leg cramps, vision problems, unusual tiredness or weakness, sweating. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: change in amount of urine. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney problems, low blood pressure, any allergies. This medication is not recommended for use if you have the following medical conditions: very low blood pressure (systolic BP less than 90), shock due to poor heart function (cardiogenic shock), other serious heart conditions (e.g., valvular stenosis, constrictive pericarditis). To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: other drugs that may lower blood pressure (e.g., ACE inhibitors, beta- blockers, calcium channel blockers, diuretics, vasodilators). Do not mix this medication with heparin, through IV lines that have had heparin in them (e.g., heparin flushes), or through IV lines containing other injectable drugs. Heparin or other IV drugs, mixed together, could decrease the effectiveness of this drug. Use a separate IV line for heparin-containing solutions and other IV drugs, if needed. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor your progress and for possible side effects.

Missed Dose

If the dose is interrupted, contact the doctor to establish a new dosing schedule/IV rate.


Store at room temperature between 56 and 86 degrees F (13 to 30 degrees C) or refrigerated between 36 and 46 degrees F (2 and 8 degrees C) away from light and moisture. Once mixed in the vial or the IV solution, this product is stable at room temperature or refrigerated for 24 hours. Discard any unused portion of the vial(s).

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).