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Neomycin sulfate, Polymyxin B sulfate and Hydrocortisone ophthalmic

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




This medication is used to treat or prevent eye or ear infections.

How To Use

For best results, use this medication exactly as directed. Continue using it for the full time prescribed. Stopping this medication too soon may not clear the infection and may result in a relapse of the illness. EYE: Apply eye drops to the affected eye(s) as follows. Wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface. Shake the eye drops before using. Tilt your head back, gaze upward and pull down the lower eyelid to make a pouch. Place the dropper directly over the eye and administer the prescribed number of drops. Look downward and gently close your eye for 1 to 2 minutes. Place one finger at the corner of the eye near your nose and apply gentle pressure. This will prevent the medication from draining away from the eye. Do not blink or rub the eye. Do not rinse the dropper after use. Replace cap tightly. If you are using another kind of eye drop, wait at least five minutes before applying other medications. EAR: To apply ear drops, wash hands first. Follow same rules to avoid contamination as noted above. Lie on your side or tilt the affected ear upward. Place the dropper directly over the ear and administer the prescribed number of drops. To roll the drops into the ear - Adults: pull the ear lobe up and back. Children: pull the ear lobe down and back. Keep the head tilted for about 2 minutes or insert a soft cotton plug if directed to do so by your doctor. Do not rinse the dropper. Replace cap after use.

Side Effects

This medication may temporarily sting or burn for a minute or two when applied. If this continues or becomes bothersome, inform your doctor. Vision may be temporarily blurred or unstable for a short while after applying eye drops. Use caution if driving or performing duties requiring clear vision. Notify your doctor immediately if you develop: skin rash, itching, burning, redness, pain, swelling in or around the eyes/ears, other vision/hearing problems. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor of all eye problems (for eye drops) or ear problems (for ear drops) and of any allergies you may have. This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.


If the condition for which this was prescribed does not improve or becomes worse after a few days, consult your doctor.

Missed Dose

If you miss a dose, use it as soon as remembered; do not use it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Discard this after the expiration date.