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Neomycin sulfate, Colistin sulfate, Hydrocortisone and Thonzonium otic

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This combination medication is used to treat bacterial infections of the ear. It also contains a medicine (hydrocortisone) that reduces swelling and itching.

How To Use

Apply or place the medication drops into the affected ear(s) usually 3 or 4 times daily; or as directed by your doctor. The dosage (number of drops) is based on your medical condition and response to therapy. Before using, clean and then dry the outer portion of the ear with a sterile cotton-tipped applicator (cotton swab). Do not stick the swab too far into the ear; doing so may cause damage to the inner ear. For accuracy and to avoid contamination, have another person insert the drops if possible. Hold container in the hand for a few minutes in order to warm it. To apply ear drops, wash hands first. To avoid contamination, do not touch the dropper tip or let it touch your ear or any other surface. Shake the container well for 10 seconds before using. Lie on your side or tilt the affected ear upward. Place the dropper directly over the ear and administer the prescribed number of drops. To help the drops roll into the ear (for adults) hold the earlobe up and back or (for children) hold the earlobe down and back. Keep the head tilted for about five minutes or insert a soft cotton plug if so directed. Do not rinse the dropper. Replace the dropper cap after use. For best results, this medication must be used routinely as directed. Continue using it for the full time prescribed, and then promptly discontinue use. Stopping this medication too soon may not clear the infection and may result in a relapse of the infection. Inform your doctor if your condition does not improve in 7 days.

Side Effects

Minor ear discomfort or irritation may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these highly unlikely but serious side effects occur: change in hearing, severe pain, skin rash, fever. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication is not recommended for use if you have the following medical conditions: certain viral infections (e.g., chickenpox, herpes simplex, shingles). Tell your doctor your medical history, especially of: perforated eardrum, other ear infections (e.g., chronic otitis media), any allergies (especially to aminoglycoside antibiotics like gentamicin or kanamycin). Tell your doctor if you are pregnant before using this medication. It is not known if this medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: other ear drops, antibiotics. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.


This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases. Do not share this medication with others.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture.