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Naphazoline HCl and Antazoline phosphate ophthalmic

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(nah-FAZZ-oh-leen WITH an-TAZZ-oh-leen, off-THAL-mick)



Naphazoline is a decongestant and antazoline is an antihistamine. The combination is used to relieve redness, puffiness, itchy and watering eyes associated with colds, allergies or eye irritations.

How To Use

This medication is for use in the eyes only. To apply eye drops, wash hands first. To avoid contamination, be careful not to touch the tip of the dropper or let it touch your eye. Tilt your head back, gaze upward and pull down the lower eyelid to make a pouch. Place dropper directly over eye and administer the prescribed number of drops. Look downward and gently close your eye for 1 to 2 minutes. Place one finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medication from draining away from the eye. Try not to blink and do not rub the eye. Do not rinse the dropper. If you are using another kind of eye drop, wait at least five minutes before applying other eye medications.

Side Effects

This medication may temporarily sting your eyes for a minute or two when you first use it. If stinging continues or becomes bothersome, inform your doctor. Inform your doctor if you develop: severe eye pain, headache, redness/itching/swelling in or around the eyes, vision problems. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: other eye problems, high blood pressure, diabetes, thyroid disorder, heart disease, asthma, allergies (especially to sulfites). Vision may be blurred or unstable for a few minutes after applying eye drops. Use caution if driving or performing duties requiring clear vision. This medication should be used only if clearly needed during pregnancy or while breast-feeding. Discuss the risks and benefits with your doctor.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you use, especially of: medication for blood pressure, antidepressants. If you are using another kind of eye drop, wait at least five minutes before applying other medications. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.


Do not share this product with others.

Missed Dose

If you should miss a dose, use it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and resume regular dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature away from sunlight. Avoid freezing. Discard the solution if it turns brown, cloudy or contains particles.