Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00
Metoprolol tartrate and Hydrochlorothiazide oral

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(met-oh-PRO-lol WITH HCTZ)


WARNING: If you have angina or have had heart problems, do not suddenly stop using this medication without first consulting your doctor. If your doctor decides you should no longer use this medication, you must stop this medication gradually according to your doctor's instructions.


Metoprolol helps to widen arteries and veins so blood flows better. Hydrochlorothiazide (HCTZ) is a "water pill" (diuretic) that rids the body of excess fluid. This combination medication is used to treat high blood pressure (hypertension).

How To Use

Take this medication exactly as prescribed. Try to take it at the same time(s) each day. This may be taken with food if stomach upset occurs. Because this medication may initially increase urination, avoid taking a dose just before bedtime. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Side Effects

Headache, lightheadedness, dizziness, loss of appetite, nausea, gas, bloating, fatigue or increased urination may occur the first several days as your body adjusts to the medication. Depression, anxiety, confusion, trouble sleeping, cold hands and feet, cough, dry skin, blurred vision, dry eyes, decreased sexual function and weight changes may also occur. If any of these effects continue or become bothersome, inform your doctor. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. Also limit your intake of alcoholic beverages and avoid overheating which will aggravate these effects. Notify your doctor if you develop: chest pain, a rapid pulse, difficulty breathing, skin rash, tingling of the hands or feet, muscle aches, fever, unusual tiredness, easy bruising or bleeding, swelling of the feet or ankles (edema), jaundice (yellowing of the eyes or skin, dark urine). This medication may cause blood disorders. Periodic laboratory tests will be done while taking this medication to monitor for these effects. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: pre-existing kidney disease, heart disease, lung disease, liver disease, diabetes, thyroid disease, any allergies (especially to sulfa drugs). This medication can increase sensitivity to sunlight. Avoid prolonged sun exposure. Wear protective clothing and use a sunscreen. Diabetics must be aware that this medication can alter blood sugar levels and may hide signs of low blood sugar such as shaking, cold sweat, confusion. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Since small amounts of this medication are found in breast milk, consult your doctor before breast-feeding.

Drug Interactions

This drug is not recommended for use with: dofetilide. Ask your doctor or pharmacist for more details. Tell your doctor of any over-the-counter or prescription medication you may take, especially of: heart medications, pain medication, thyroid medication, cimetidine, oral diabetic medication, birth control pills, St John's wort. Do not take any medication for cough, colds, hay fever, allergies or weight control without first checking with your doctor or pharmacist. These medications may contain ingredients which can increase blood pressure. Limit your intake of alcoholic beverages while taking this medication. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include slow heart rate, dizziness, weakness, fainting, coughing, and trouble breathing.


It is important to have your blood pressure checked regularly while taking this medication. Learn how to take your blood pressure and understand the readings. Discuss this with your doctor or pharmacist.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).