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Lidocaine and Prilocaine topical

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(LIE-doh-cane WITH PRILL-oh-cane)



This medication is an anesthetic used on the skin to prevent pain. It is used before certain procedures such as inserting IV lines, skin grafts or skin laser surgery where numbing of the skin and surrounding area is necessary.

How To Use

This medication is for use on the skin only. Apply to the skin area at the proper time as directed. The length of time for the medication to stay on the skin depends on the type of procedure you will undergo. However, it should be applied for a minimum of 1 hour before the procedure. To apply, squeeze out the prescribed amount of cream directly onto the skin. Do not rub in. Cover with air-tight dressing (e.g., Tegaderm). Remove the paper frame and seal the edges only allowing the cream to remain in a thick layer. Just prior to your medical procedure or when directed, remove the dressing and cream and clean the area thoroughly. Do not use larger amounts than prescribed or leave it in place for longer than directed since the chance for side effects may be increased. Avoid contact with the eyes. Use cautiously near the nose and mouth.

Side Effects

This medication may cause temporary redness, tingling or lightening of the skin. If these symptoms continue or become worse inform your doctor. Notify your doctor immediately if you develop blistering of the skin where the medication is applied. Also report: breathing trouble, nervousness, dizziness, mental confusion. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: blood disorders, liver disease, allergies (especially to anesthetics). This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication is found in breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take, including: antibiotics (esp. sulfas and dapsone), nitrates (e.g., nitroglycerin), phenytoin, phenobarbital, acetaminophen, benzocaine, chloroquine, phenacetin, quinine, primaquine, pamaquine, nitroprusside, lidocaine-like heart medicines (antiarrhythmics). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.


Because this medication numbs the area where applied, be careful not to bump, scratch or rub the skin. You will not feel it. Use caution until numbness fades and feelings return.

Missed Dose

If you miss a dose, apply it as soon as remembered; do not use it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat. Check the expiration date on the tube and discard any expired medication.