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Leuprolide acetate subcutane.

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is a synthetic hormone. When it is used, the body stops producing testosterone hormones in males and estrogen hormones in females. When the medication is stopped, hormone levels return to normal. Leuprolide is used in the treatment of prostate cancer in men, early puberty in children, and anemia (due to uterine fibroid tumors) in women.



This medication may also be used for ovarian or breast cancer in women.

How To Use

This medication is given as an injection under the skin (SC). Do not stop using this without your doctor's permission.

Side Effects

Adults - This medication may cause nausea, vomiting, hot flashes, night sweats, bone pain, swelling of feet and ankles, headache, or difficulty urinating the first few days as your body adjusts to the medication. Notify your doctor if these symptoms continue or become bothersome. This medication may cause reduced sexual desire. Notify your doctor if you develop any of the following while using this medication: rapid heartbeat, chest pain, breathing difficulties, fever, chills, painful urination, testicular or prostate pain (men), persistent irritation at the injection site. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: severe headache, vision changes, severe drowsiness, unusual or one-sided weakness. Children - This medication may cause general pain, acne, irritation at injection site, vaginal inflammation or discharge (females). The medication may rarely cause swelling of hands or feet, weight gain, headache, nervousness, drowsiness, nausea, vomiting, gingivitis, or trouble swallowing. Notify your doctor if these symptoms continue or become bothersome. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: osteoporosis or other bone disease, allergies. Leuprolide should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Use reliable, non-hormonal birth control while using this medication. It is not known if leuprolide is excreted into breast milk. The manufacturer of leuprolide says breast-feeding should not be undertaken while using this drug. Because this medication can affect the production of sperm in men, a reliable form of birth control is recommended while using this medication.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take including: phenytoin, corticosteroids (e.g., prednisone). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


This medication must be used under close medical supervision. Discuss the risks and benefits of this therapy with your doctor.

Missed Dose

If you miss a dose, use it as soon as remembered. If you do not remember until the next day, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the doses.


Refer to the manufacturer-specific storage information that comes with this product, and consult your pharmacist.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).