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Leuprolide acetate intramusc.

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Leuprolide has various uses, among them are: treatment for prostate cancer, early puberty in children and for problems of the uterus in women.



This drug may also be used for breast or ovarian cancer.

How To Use

This medication is injected into a muscle (I.M.) and must be used under close medical supervision. This long acting form of leuprolide is called a depot. It is slowly released into the bloodstream and is given at various intervals. The dosing frequency depends on which product was prescribed by your doctor. If you are directed to inject this drug yourself, make sure you know exactly how to use this and how often. Consult your doctor or pharmacist if you are uncertain or have any questions. Do not stop using this medication without your doctor's permission.

Side Effects

This medication may cause nausea, vomiting, hot flashes, night sweats; bone, joint or muscle pain; swelling of hands, feet or ankles; headache; vaginal dryness, inflammation or discharge; reduced sexual desire, mental/mood changes, dizziness, drowsiness, weight gain, inflamed gums, trouble swallowing, persistent pain at injection site, acne or difficulty urinating. Notify your doctor promptly if these symptoms persist or worsen. Notify your doctor promptly if you develop any of the following symptoms: rapid heartbeat, chest pain, fever, unusual weakness, testicular or prostate pain (men), vaginal bleeding (women). Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: severe headache, vision changes, severe drowsiness, unusual or one-sided weakness. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: urinary problems, alcohol or smoking dependence, bone diseases, cancer/lesions of the spine, abnormal vaginal bleeding, any allergies you may have. Limit alcohol intake, as it may intensify drug side effects. Caution is advised when performing tasks requiring alertness (e.g., driving), as this drug may cause dizziness or drowsiness. Leuprolide should not be used during pregnancy. If you become pregnant or think you may be pregnant, inform your doctor immediately. Discuss birth control methods with your doctor. It is not known if leuprolide is excreted into breast milk. Because the effects of leuprolide on a nursing infant are unknown, do not breast-feed. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all over-the-counter and prescription medication you may use including: corticosteroids (e.g., prednisone), phenytoin. Certain lab tests may be affected by this drug. Inform all your healthcare providers you use this medication. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Lab tests will be done periodically to monitor your progress.

Missed Dose

It is very important you do not miss any doses. However, if you do miss a dose, contact your doctor promptly to establish a new schedule.


Store vial and ampule of diluent at room temperature below 77 degrees F (25 degrees C). After mixing, discard any unused solution. Do not freeze.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).