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Lamivudine oral
LAMIVUDINE-HBV - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

LAMIVUDINE-HBV - ORAL

(lam-EYE-view-deen)

COMMON BRAND NAME(S): Epivir HBV

WARNING: Lactic acid build-up in the blood (lactic acidosis) and severe liver disease, including death, have been reported with the use of lamivudine, either alone or in combination with other drugs used to treat human immunodeficiency virus (HIV) infection (e.g., zidovudine, ritonavir). HIV counseling and testing should be offered both before and during treatment to all patients using lamivudine-HBV. Lamivudine-HBV contains a lower dose of the drug lamivudine used to treat HIV infection. Use of lamivudine-HBV in patients with unknown or untreated HIV infection could result in resistant strains of HIV. Consult your doctor or pharmacist for more information.

Uses

Lamivudine-HBV is a nucleoside reverse transcriptase inhibitor used to treat a chronic viral infection of the liver (hepatitis B). It works by slowing the growth of the virus. It is not a cure for hepatitis B and does not prevent the passing of hepatitis B to others.

How To Use

Take this medication by mouth, usually once daily; or take as directed by your doctor. May take with or without food. Take this medication exactly as prescribed. Do not increase or decrease your dose or stop taking this medication unless directed to do so by your doctor or pharmacist. The safety and effectiveness of this medication after one year of use has not been established. The optimal duration of use of this medication is unknown. Consult your doctor or pharmacist for more information. Lamivudine-HBV is not appropriate for the treatment of patients infected with both hepatitis B and HIV. An HIV test is recommended both before and during treatment to ensure you receive appropriate treatment. Consult your doctor or pharmacist for more information. Worsening of your condition, decreased response to therapy, or the occurrence of resistant strains of the virus may occur during or after treatment. Promptly report any new symptoms that occur during or after treatment to your doctor.

Side Effects

Nausea, vomiting, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, contact your doctor or pharmacist promptly. Tell your doctor immediately if any of these side effects occur: fatigue, sore throat, fever. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, persistent or severe stomach pain, yellowing eyes or skin, dark urine. Tell your doctor immediately if any of these highly unlikely but serious side effects occur: rapid breathing, tingling or numbness of the hands or feet. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history especially of: infection with HIV, kidney problems, liver problems, blood disorders, pancreas problems, alcohol use, allergies (especially drug allergies). This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages. Liquid preparations of lamivudine may contain sugar (sucrose); caution is advised in patients with diabetes. If you are diabetic, close monitoring of your blood sugar is recommended as you begin using this drug. Ask your doctor or pharmacist for more details. Caution is advised when using this drug in children (especially in children with pancreatitis) because they may be more sensitive to the effects of this drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication has not been shown to affect the transmission of hepatitis B from mother to infant. Consult your doctor for more information. It is not known if lamivudine passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription drugs you may use, especially of: trimethoprim/sulfamethoxazole, current or previous use of HIV medications (e.g., lamivudine, zidovudine), zalcitabine. This product can affect the results of certain lab tests (e.g., liver). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control or emergency room immediately.

Notes

Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor your progress. Keep all laboratory and medical appointments during and for several months after treatment.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature between 68 and 77 degrees F (20 to 25 degrees C) away from light and moisture.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).