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Hyaluronidase injection

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is an enzyme used to help the body absorb other medications (e.g., anesthetics) or water preparations (hypodermoclysis) that are given by injection either under the skin (e.g., subcutaneously, intradermally) or into the muscle (IM).

How To Use

Follow all instructions for the proper mixing and dilution with correct IV fluids. Consult your pharmacist. A skin test is recommended before the first dose to test for sensitivity to this medication. Consult your doctor or pharmacist for details. Give this medication by injection directly under the skin (subcutaneously) or into a muscle (IM), or as directed by the doctor. This medication should not be given into the vein (IV). This medication may be directly added (mixed) with other medications prior to injection. Consult your pharmacist. This medication should be checked visually for particles or discoloration before use. If present, do not use the liquid.

Side Effects

Common side effects to this medication are rare. Tell your doctor immediately if any of these very unlikely but serious side effects occur: pain/redness/rash/swelling at the injection site, fast or irregular pulse. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: current infections, cancer, any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: local anesthetics (e.g., lidocaine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Do not share this medication with others. Laboratory and/or medical tests may be performed to monitor for side effects and response to treatment.

Missed Dose

If the dose is interrupted, contact your doctor or pharmacist immediately to establish new dosing.


Store vials at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture. Consult your pharmacist for details about storage and stability after mixing and dilution in correct IV fluids. Discard any unused liquid.