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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to treat the panic and anxiety symptoms associated with panic disorder. Alprazolam belongs to a class of medications called benzodiazepines. These medicines work directly on the brain and nerves (central nervous system) to produce a calming effect.

How To Use

Take this medication by mouth once daily usually in the morning; or as directed by your doctor. This medication should be swallowed whole; do not crush or chew the tablets. Avoid eating grapefruit or drinking grapefruit juice while being treated with this medication unless your doctor instructs you otherwise. Use this medication exactly as prescribed. Do not increase your dose, take it more frequently, or use it for a longer period of time than prescribed, because this drug may be habit forming. If using this drug for an extended period of time, do not suddenly stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped. Your dose will need to be gradually decreased to avoid side effects such as seizures. When used for an extended period, this medication may not work as well and may require different dosing. Talk with your doctor if this medication stops working well.

Side Effects

Drowsiness, dizziness, headache, tiredness, clumsiness, decreased interest in sex, decreased appetite, nausea, constipation, or joint pain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur: mental / mood changes, confusion, slurred speech or difficulty speaking, difficulty remembering things. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (acute narrow angle), allergy to any other benzodiazepines (e.g., diazepam, lorazepam). Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, lung disease, history of drug dependence, alcohol use, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Avoid alcoholic beverages. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the drowsiness effect. This medication is not recommended for use during pregnancy. Consult your doctor for more details. This medication passes into breast milk. Breast-feeding while using this medication is not recommended.

Drug Interactions

This drug should not be used with the following medications because very serious interactions may occur: azole antifungals (e.g., ketoconazole, itraconazole), sodium oxybate. If you are currently using any of these medications, tell you doctor or pharmacist before starting alprazolam. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: antidepressants (e.g., nefazodone, fluvoxamine, fluoxetine), anti-seizure medication (e.g., carbamazepine), certain herbal products (e.g., St. John's wort, kava), clozapine, cimetidine, fluconazole, HIV medications (e.g., delavirdine, or HIV protease inhibitors such as ritonavir), macrolide antibiotics (e.g., clarithromycin, erythromycin), rifamycins (e.g., rifampin). Report all drugs that cause drowsiness such as: medicine for sleep (e.g., sedatives), tranquilizers, anti-anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, antihistamines that cause drowsiness (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that could cause drowsiness. Ask your pharmacist about the safe use of those products. See How To Use section for information on drug-food interactions. Cigarette smoking decreases blood levels of this medication (hepatic enzyme induction). Tell your doctor if you smoke or if you have recently stopped smoking. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: severe drowsiness, severe confusion, loss of coordination, or unconsciousness.


Do not share this medication with others. It is against the law.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature of 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59 and 86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.