Find & Manage Your Patient Assistance Programs
Estimated patient savings $600,000,000.00

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(meth-EN-uh-meen/METH-ih-leen blue/sa-LI-si-late/SOE-dee-um bi- FOS-fate/hye-oh-SYE-a-meen)

COMMON BRAND NAME(S): Disurex D/S, Urelle, Urimar-T, Urogesic-Blue


This medication contains anti-infective, pain-relieving, and antispasmodic ingredients. It is used to treat the discomfort, pain, and urinary urgency/frequency symptoms related to urinary tract infections.

How To Use

Take this medication by mouth, usually four times a day with food; or take as directed by your doctor. Take each dose with a full glass of water (8 oz. or 240 ml) and drink plenty of fluids while taking this medication. To avoid blue-green stains on the skin or mouth, make sure your hands are dry and that the tablets are swallowed quickly with plenty of fluid. Take this medication at evenly spaced intervals. Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a relapse of the infection.

Side Effects

Nausea, vomiting, stomach cramps, drowsiness, or dry mouth may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if you have any of these unlikely but serious side effects: decreased sweating, flushing, mental/mood changes, pain or difficulty with urination, pink urine. If you notice any of the following unlikely but very serious side effects, stop taking this medication and consult your doctor or pharmacist immediately: dizziness, blurred vision, unusually fast heartbeat. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. To relieve dry mouth, suck on (sugarless) hard candy or ice chips, chew (sugarless) gum, drink plenty of water, or use a saliva substitute. This medication may cause your urine and stools to turn blue- green in color. This harmless effect is temporary and will disappear when the medication is stopped. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: eye problems (e.g., glaucoma), kidney problems, heart disease (e.g., arrhythmia, heart failure), high blood pressure, stomach problems (e.g., ulcers, obstruction), myasthenia gravis, bladder or prostate problems (e.g., obstruction), bleeding problems (e.g., hemophilia), any allergies (especially to aspirin, salicylates, or belladonna). This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. Caution is advised when using this drug in children because they may be more sensitive to the side effects of the drug. Caution is advised when using this drug in the elderly because they may be more sensitive to the side effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Some of the ingredients in this medication (methenamine and hyoscyamine) pass into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription drugs you may use, especially: heparins, medications for diabetes (e.g., glyburide, glipizide), aspirin or salicylate medications, carbonic anhydrase inhibitors (e.g., acetazolamide), MAO inhibitors (e.g., furazolidone, moclobemide, phenelzine, procarbazine, linezolid, selegiline), gout medicine (e.g., probenecid, sulfinpyrazone), antimuscarinic/anticholinergic drugs (e.g., atropine, oxybutynin, propantheline), drugs to make urine alkaline (e.g., potassium citrate, sodium bicarbonate), thiazide diuretics (e.g., hydrochlorothiazide), antacids, anti-diarrhea medications (e.g., kaolin-pectin), ketoconazole, valproic acid, methotrexate. Tell your doctor if you take any drugs that cause drowsiness such as: medicine for sleep, sedatives, tranquilizers, anti- anxiety drugs (e.g., diazepam), narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine or tricyclics such as amitriptyline), anti-seizure drugs (e.g., carbamazepine), muscle relaxants, certain antihistamines (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of these products. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include seizures, trouble breathing (e.g., rapid, shallow breathing or slowed breathing).


Do not share this medication with others.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from light and moisture.