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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: This medication can cause severe, even fatal, side effects including blood cell problems (decreased white blood cells and platelets). Immediately notify your doctor if you have signs of an infection (such as persistent sore throat or fever), unusual fatigue, dark or pink-reddish urine, itching, rash, mouth sores or irritation (stomatitis), or persistent diarrhea. Your doctor will be closely monitoring certain lab tests (e.g., white blood cells, platelets) before starting therapy and before you receive each injected dose or written prescription.


This medication is used to treat arthritis (rheumatoid) along with other medications. Also, this medication is usually used in combination with rest and physical therapy for arthritis.



This drug may also be used for other forms of arthritis.

How To Use

Shake this suspension well before using. This drug is given by injection into a muscle (IM), generally once a week initially. As treatment continues, the drug is generally given every 3-4 weeks. This should not be given by vein (IV). To minimize side effects, it is advised to be lying down when receiving this drug, and for ten minutes afterward. Beneficial effects occur slowly and 6 to 8 weeks treatment may be required before improvement occurs. Treatment is continued indefinitely, depending on any side effects and/or improvement in your condition.

Side Effects

Temporary joint pain may occur. Also, for short periods after injections, flushing, dizziness, sweating, headache or blurred vision may occur. If these persist or worsen, notify your doctor promptly. Report promptly: itching, skin redness or rash, sore mouth, stomach upset, metallic taste, persistent diarrhea, skin color change, vaginal discomfort. Very unlikely but report promptly: unusual bleeding or bruising, pink-reddish urine, fever or persistent sore throat, unusual fatigue, yellowing eyes or skin, abdominal pain, vision changes, confusion, seizures, hair loss. In the unlikely event an allergic reaction occurs, contact your doctor immediately. Symptoms include: difficulty breathing, fainting or dizziness, swelling. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), blood disorders, severe high blood pressure, blood vessel or heart disease, skin rash/itching, intestinal problems (colitis), severe diabetes, lupus (SLE), cancer radiation treatment, urticaria, liver problems, kidney problems. This drug may cause sun sensitivity reactions (sunburn-like). Use sunscreens with UVA and B, and wear protective clothing. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This drug is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all nonprescription and prescription medication you use, especially of: phenylbutazone, penicillamine, anti-cancer drugs, anti-malarials, immune suppression drugs (e.g., azathioprine). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include diarrhea, hives, and severe itching.


Laboratory tests will be done during therapy to reduce the chance of side effects. This drug may interfere with certain blood iodine tests. Do not share this medication with others.

Missed Dose

If you miss a dose, consult your doctor or pharmacist promptly to establish a new dosing schedule.


Store at room temperature between 59 and 86 degrees F (15-30 degrees C) away from light and moisture. Do not freeze.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).