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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.




WARNING: Flumazenil can cause seizures, especially in patients who have been on benzodiazepines (e.g., diazepam) for a long time or if patient has taken too much of a benzodiazepine (overdose).


This medication reverses the sedative effects of certain medications. It is used to counteract effects of certain anesthetics. It may also be used in the treatment of drug overdose.

How To Use

This medication is given by injection by a health care professional. The dose and frequency of use is based on your condition and response. You will be monitored closely while receiving this medication.

Side Effects

Headache, sweating, irritation at the injection site, blurred vision, flushing, nausea, vomiting or dizziness may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor immediately if you develop: rapid heart rate, skin rash, mood changes, irritability, anxiety, mental confusion, nervousness, tremor, abnormal/jerky muscle movements, depression. Avoid intake of alcoholic beverages or any prescription or nonprescription medication for at least one day unless directed to do so by your doctor. Be aware that sedation may persist and that your memory and judgment may be impaired for up to one day. Therefore, avoid driving and do not perform tasks requiring alertness until you no longer feel dizzy. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have a history of: seizures, panic attacks, alcohol or drug dependency, breathing disorders, heart disease, liver disease, head injury, allergies (especially drug allergies). This drug should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding. This drug is not recommended for use in children.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take, including: antidepressants, anti-seizure drugs, narcotic pain relievers, sleeping pills, sedatives. Avoid the use of alcohol while taking this medication. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include emotional or mood changes, agitation, and convulsions.


This medication reverses the sedative effects of other medication but memory and judgment may still be vague for up to one day.

Missed Dose

This medication is administered by a health care professional who will determine your dose and schedule. There is no need for follow-up doses.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.