Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

DEOXYRIBONUCLEASE (DORNASE ALPHA) - INHALATION

(dee-OX-ee-rye-bow-NEW-klee-aze, DOOR-naze Al-fa)

COMMON BRAND NAME(S): Pulmozyme

Uses

This medication works in the lungs to break up thick, sticky mucous that clogs airways. It helps improve breathing and reduces the risk of lung infections in persons with cystic fibrosis. This is used with other medications and physical therapy in the management of cystic fibrosis.

How To Use

This medication is inhaled into the lungs using special breathing machine called a nebulizer usually once or twice a day as prescribed. A health care professional will demonstrate the proper way to prepare the medication and use the machine. Do not increase your dose or take this more frequently than directed. Your condition will not improve faster but the chance for side effects will be increased. Do not stop using this medication without first consulting your doctor.

Side Effects

Laryngitis, hoarseness or dry throat may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: unusual coughing or wheezing, a rash, chest pain, irritation or redness of the eyes, breathing trouble. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor if you have: other illnesses, any allergies. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription or medication you may take. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately.

Notes

To receive maximum benefit from this medication, it is important to know how to use the inhaler properly. Be sure you understand and follow the directions closely.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Store the medication in the refrigerator. Do not store it in the bathroom. Properly discard of any unused medication after the expiration date on the label.