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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.



COMMON BRAND NAME(S): Cervidil, Prostin E2


This medication is used to produce an abortion. It is also used for certain conditions of the womb.

How To Use

This drug is used vaginally. Bring the suppository to room temperature and remove the foil before use. The drug is inserted high in the vagina, and you must remain in a reclined or lying down position for 2 hours after insertion. More doses are given at 3-5 hour intervals until desired effect occurs. This drug is used for a maximum of 2 days.

Side Effects

Vomiting, fever, diarrhea, headache, chills and dizziness may occur. If these persist or worsen, notify your doctor immediately. Report immediately: fainting, chest pain/tightness, trouble trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this drug, tell your doctor your medical history, including: allergies (especially drug allergies), pelvic infections, heart disease, kidney problems, liver disease, lung disease, asthma, high or low blood pressure, anemia, diabetes, seizure disorder, infections in the vaginal area, womb scarring, previous cesarean section (c-section) birth, uterine surgery. This drug is not indicated for use if the fetus is mature enough to survive apart from the womb. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all nonprescription and prescription medication you may use, especially of: other drugs that can stimulate the uterus (oxytocics) such as other prostaglandins (e.g., misoprostol). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Use under direct medical supervision.

Missed Dose

If a dose is missed, consult with your doctor to establish a new dosing schedule.


Store in a freezer not above -4 degrees F (-20 degrees C) away from light and moisture.