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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.


(pram-OX-een WITH hi-dro-KOR-tih-sown)



Pramoxine is a topical anesthetic used to relieve minor pain, itching and discomfort. Hydrocortisone reduces inflammation and itching. This combination medication is used in the treatment of certain conditions of the anal region.

How To Use

Read patient direction leaflet if provided by manufacturer. Shake canister well before using. For perianal use: spray a small amount onto a tissue and gently rub into the affected area. For rectal use: use the provided applicator. Holding the container upright, insert into the tip of the applicator. Plunger should be drawn up all the way, but not pulled out. Slowly press down on the container cap until foam reaches the fill line of the applicator. Remove applicator from the container. Holding the applicator by the barrel, gently insert tip into the rectum. Push the plunger to expel foam, then withdraw the applicator. Pull apart the applicator parts and clean thoroughly with warm water. Do not insert any part of the container into the rectum. Do not use this more often than prescribed since the chance for side effects may be increased. Avoid contact with the eyes.

Side Effects

This medication may cause temporary redness or minor irritation when first applied. If these symptoms continue or become worse inform your doctor. Notify your doctor if you develop swelling, itching or rash where the medication is applied. Very unlikely to occur but report promptly the following side effects: unusual weakness, weight loss, nausea/vomiting, fainting, dizziness, vision changes. If you notice other effects not listed above, contact your doctor or pharmacist.


Before using this medication tell your doctor your medical history, especially of: eye problems, blood diseases, infections, liver disease, any allergies. Though very unlikely, it is possible this medication will be absorbed into your bloodstream. This may have undesirable consequences that may require additional corticosteroid treatment. This is especially true for children and for those who have used this for an extended period if they also have serious medical problems such as serious infections, injuries or surgeries. This precaution applies for up to one year after stopping use of this drug. Consult your doctor or pharmacist for more details. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. This medicine may be harmful if swallowed.


Use this only for the condition for which it was prescribed. If the condition does not improve or becomes worse after a few days, notify your doctor. Inform all your doctors you use, or have used, this medication.

Missed Dose

If you miss a dose, apply it as soon as remembered; do not use it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat. Check the expiration date and discard any expired medication.