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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





Mannitol is used to increase urine production (diuretic). It is used to treat or prevent medical conditions that are caused by an increase in body fluids/water (e.g., cerebral edema, glaucoma, kidney failure). This medication is frequently given along with other diuretics (e.g., furosemide, chlorothiazide) and/or IV fluid replacement.



This drug may also be used, along with other diuretics, to help remove certain drugs/poisons from the body (e.g., aspirin, barbiturates, bromides, carbon monoxide)

How To Use

A small test dose of this medication may be given as directed by your doctor. This small test dose should help determine your response to treatment. Give this medication by vein (IV) exactly as directed by your doctor. The dosage is based on your weight, medical condition, and response to treatment. This medication may contain small particles in the IV solution. It is very important to use an IV filter while giving this solution. Consult your pharmacist for the proper IV filter and its instructions for use. Under certain conditions (e.g., cool temperatures), crystals may form in this medication. Although these crystals do not affect the medication solution, the crystals must be dissolved before using this product. Consult your pharmacist for more information. Before using check this product for particles or discoloration. If either is present do not use the liquid. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.

Side Effects

Headache, nausea, diarrhea, vomiting, dry mouth, and irritation/pain/swelling at the injection site may occur. If any of these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if any of these serious side effects occur: blurred vision, change in amount of urine, back pain. Tell your doctor immediately if any of these unlikely but serious side effects occur: mental/mood changes, trouble breathing, slow or shallow breathing, unusual swelling. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: uncontrolled muscle movements (tremor), seizures, chest pain, black/dead-looking skin (necrosis). An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor your medical history, especially of: kidney problems, liver problems (e.g., cirrhosis), heart disease, lung or breathing problems (e.g., pulmonary edema), nervous system problems, chemical disorders (e.g., acid/base balance, electrolyte disorders), any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially: lithium, aminoglycoside antibiotics (e.g., gentamicin, kanamycin, tobramycin). Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: decrease in amount of urine, seizures, severe trouble breathing.


Do not share this medication with others. Laboratory and/or medical tests (e.g., renal function, fluid/electrolytes balance) may be performed to monitor your progress.

Missed Dose

If your dose is interrupted or stopped, consult your doctor to establish a new dosing schedule/IV rate.


Store at room temperature between 56 and 86 degrees F (13 to 30 degrees C) away from light. Do not refrigerate or freeze.