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ONXOL
PACLITAXEL - INJECTION

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

PACLITAXEL - INJECTION

(pack-lih-TAX-el)

COMMON BRAND NAME(S): Taxol

WARNING: Infrequently, serious (sometimes fatal) allergic reactions have occurred with paclitaxel use. Patients who experience severe allergic reactions must never again use this drug. Seek immediate medical attention if you develop signs of an allergic reaction such as rash, itching, breathing trouble, swelling or dizziness. This medication can lower the body's ability to fight an infection. Notify your doctor promptly if you develop signs of an infection such as fever, chills or persistent sore throat. Blood tests (e.g., white blood cell counts) are recommended during paclitaxel use. This medication must be given in an appropriate setting.

Uses

Paclitaxel is used to treat various types of cancer.

How To Use

This medication is given by continuous infusion into a vein over 24 hours. This is usually given once every three weeks, but the dose may be adjusted based on your progress. It is usually administered in a hospital setting where you can be monitored closely. Medication to prevent side effects is usually given before you receive paclitaxel.

Side Effects

Nausea, vomiting, stomach upset, muscle aches, joint pain, diarrhea, mouth sores and reversible hair loss may occur. If any of these effects persist or worsen, inform your doctor promptly. Notify your doctor promptly if you develop: chest pain, abnormal heartbeat, breathing trouble, fever, unusual bruising or bleeding, tingling of the hands or feet. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, especially of: heart disease, liver disease, bone marrow disorders, infections, any allergies you may have. Because this medication can lower your body's ability to fight an infection, avoid touching your eyes or inside your nose without first washing your hands. Use caution with sharp objects like safety razors or nail cutters and avoid activities such as contact sports in order to lower the chance of getting cut, bruised or injured. Do not have immunizations/vaccinations without consent of your doctor, and avoid contact with people who have recently received oral polio vaccine. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the effects on the bone marrow (myelosuppression). Paclitaxel is not recommended for use during pregnancy. Consult your doctor before using this drug. It is not known if paclitaxel passes into breast milk. Breast- feeding is usually stopped while using anticancer drugs. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor or pharmacist of all prescription and nonprescription medications you may use, especially of: ketoconazole, all anti-cancer medications, St John's wort. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include tingling of the hands or feet; severe mouth sores, or trouble breathing.

Notes

Laboratory tests will be done periodically to monitor your progress.

Missed Dose

Discuss the dosing schedule with your doctor. Do not double the dose to catch up.

Storage

Store original vials in the refrigerator. The infusion solution can be stored at 77 degrees F (25 degrees C). Check the expiration date and discard any unused medication after that time.

Medical Alert

Your condition can cause complications in a medical emergency. For enrollment information call MedicAlert at 1-800-854-1166 (USA), or 1-800-668-1507 (Canada).