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NEFAZODONE HCL
NEFAZODONE - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

NEFAZODONE - ORAL

(neh-FAZZ-oh-doan)

COMMON BRAND NAME(S): Serzone

WARNING: Nefazodone rarely may cause serious (potentially fatal) liver disease. Seek immediate medical attention if you develop: dark urine, extreme fatigue, persistent loss of appetite, stomach pain, yellowing eyes/skin. Tell your doctor or pharmacist if you have a history of liver problems or abnormal liver function tests (LFTs) before taking this medicine. Your doctor may perform laboratory tests (e.g., liver function) to monitor your progress. If your doctor stops your nefazodone treatment because of liver problems/abnormal liver tests, you should not take this drug again. Consult your doctor or pharmacist for more details.

Uses

This medication is used in the treatment of depression.

How To Use

Take this medication by mouth exactly as prescribed. During the first few weeks your doctor may gradually increase your dose to allow your body to adjust to the medication. Do not take this more often, increase your dose or stop taking this without first consulting your doctor.

Side Effects

The most common side effects are sleepiness, dry mouth, nausea, dizziness (especially when standing), constipation, weakness, blurred vision or changes in vision, or mental confusion. If any of these effects persist or worsen, notify your doctor promptly. Notify your doctor immediately if you develop: irregular heartbeat, skin rash, seizures. Males: if you develop a painful, prolonged erection lasting more than 4 hours, seek immediate medical attention. This uncommon condition can result in permanent injury. Nefazodone can rarely cause serious, possibly fatal, liver problems. Seek immediate medical attention if any of these symptoms occur: stomach pain, dark urine, yellowing eyes/skin, unusual fatigue. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor if you have: liver problems, heart disease, history of seizures, any allergies (including trazodone). It is recommended to limit consumption of alcohol while taking this medication. Caution is advised when operating machinery or performing tasks needing alertness, since this medication can cause drowsiness or dizziness. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication is excreted into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of any over-the-counter or prescription medication you may take, including: terfenadine, astemizole, alprazolam, triazolam, buspirone, MAOI drugs (e.g., linezolid, phenelzine, tranylcypromine, selegiline, furazolidone), cisapride, carbamazepine, fluoxetine, paroxetine, sertraline, fluvoxamine, venlafaxine, sumatriptan, dexfenfluramine, fenfluramine, sibutramine, "statins" (e.g., lovastatin), narcotic pain drugs (e.g., codeine), pimozide, cyclosporine, tacrolimus. This medication should not be used within 14 days after discontinuing an MAOI. An MAOI should not be taken within 1 week of stopping nefazodone. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, vomiting, sluggishness, and increased sweating.

Notes

It may take several weeks of continued therapy before the full effects of this medication occur. Keep all regular medical or laboratory appointments. Medical/laboratory tests (e.g., liver function) may be performed to monitor your progress.

Missed Dose

Try to take each dose at the scheduled time. If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Store this medication at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom. Keep this and all medications out of the reach of children.