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Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.





This medication is used to prevent Mycobacterium avium complex (MAC) disease in susceptible individuals (CD4 counts of less than 200).

How To Use

Take this medication by mouth as directed. It is usually taken once or twice a day. This is best taken on an empty stomach but may be taken with food if stomach upset occurs. For best results, take each dose at evenly spaced intervals around the clock. This will ensure a constant level of medication in your blood. Do not stop taking this medication without first consulting your doctor.

Side Effects

Stomach upset, stomach cramps, nausea, headache, altered taste may occur especially the first several days as your body adjusts to the medication. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor if you develop: chest pain, vomiting, skin rash, muscle aches, flu-like symptoms, vision changes. Also report any changes in the symptoms of your illness. This medication may cause skin, tears, saliva, sweat, urine and stools to turn orange-brown in color. This is normal and will change when the drug is stopped. Do not be alarmed. Expect this effect. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.


Tell your doctor if you have: blood disorders, tuberculosis, any allergies. Soft contact lenses may become permanently stained since this medication discolors tears. Avoid wearing soft contact lenses while taking this medication. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding.

Drug Interactions

This drug is not recommended for use with: delavirdine. Ask your doctor or pharmacist for more details. Inform your doctor about all the medicines you may use (both prescription and nonprescription), especially of: warfarin, oral medicines for diabetes, azole antifungals (e.g., itraconazole, ketoconazole), theophylline, halothane, verapamil, certain protease inhibitors (e.g., nelfinavir), corticosteroids (e.g., prednisone), disopyramide, beta-blockers (e.g., metoprolol), isoniazid, digitoxin, quinidine, mexiletine, phenytoin, cyclosporine, zidovudine, live vaccines. Rifampin can decrease the effectiveness of oral contraceptives. Discuss the use of other birth control methods with your doctor. Do not start or stop any medicine without doctor or pharmacist approval.


If overdose is suspected, contact your local poison control center or emergency room immediately.


Laboratory tests will be done periodically while taking this medication to monitor its effects.

Missed Dose

If you miss a dose, take it as soon as remembered; do not take it if it is near the time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.


Store at room temperature between 59 and 86 degrees F (15 to 30 degrees C) away from heat and light. Do not store in the bathroom.