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MISOPROSTOL
MISOPROSTOL - ORAL

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

MISOPROSTOL - ORAL

(my-so-PROST-ohl)

COMMON BRAND NAME(S): Cytotec

WARNING: Use of this drug during pregnancy can cause abortion, premature birth, or birth defects. Rupture of the womb (uterus) has occurred in pregnant women using misoprostol to start labor, or when using it to cause abortion after the eighth week of pregnancy. Misoprostol should not be taken to reduce the risk of ulcers due to aspirin or related drugs (NSAIDs such as ibuprofen) if you are pregnant. This drug should not be used to reduce the risk of NSAID ulcers if you are of childbearing age, unless you are at high risk of having an ulcer, or ulcer complications. If a woman must use this, 4 requirements must be met: 1) negative pregnancy test within 2 weeks before starting use of misoprostol; 2) be able to use effective measures to prevent pregnancy (contraception); 3) receive oral and written warnings on the dangers of misoprostol use in women of childbearing age, and the risks of possible birth control failure; 4) begin taking this only on the second or third day of the next normal menstrual period. This medication must not be shared with others.

Uses

This medication is used to prevent ulcers in persons taking nonsteroidal anti-inflammatory drugs (NSAIDs, including aspirin), especially in persons at risk for developing ulcers or those with a history of ulcers. This medication is also used in combination with another drug to end a pregnancy (abortion).

How To Use

This medication is best taken with meals and at bedtime to minimize the incidence of diarrhea. Avoid taking magnesium-containing antacids such as Mylanta or Maalox while on this medication. These types of antacids may increase the frequency/severity of diarrhea caused by misoprostol. Read antacid labels carefully to check for magnesium content. It is important to take this medication exactly as prescribed. Do not increase your dose or take more often than prescribed.

Side Effects

This medication causes diarrhea that usually stops after 8 days. Nausea, vomiting, stomach pains, gas, indigestion, or headache may occur. If these effects persist or worsen, notify your doctor promptly. Tell your doctor immediately if these unlikely but serious side effects occur: menstrual irregularities, unusual/heavy vaginal bleeding. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, especially: stomach/intestinal disorders, prior Cesarean birth or uterine surgery, five or more previous pregnancies, any allergies. Misoprostol must not be used during pregnancy (see Warning section). Use effective birth control while taking this drug for ulcer prevention. If you become pregnant or think you may be pregnant, inform your doctor immediately. It is not known if misoprostol is excreted into breast milk. The manufacturer of this drug advises against breast-feeding while using misoprostol because it may harm a nursing infant.

Drug Interactions

Tell your doctor of all medicines you may use (both prescription and nonprescription) especially: magnesium- containing antacids. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include sleepiness, tremors, seizures, difficulty breathing, stomach pain, diarrhea, fever, and slow heart rate.

Notes

Do not allow anyone else to take this medication.

Missed Dose

Take any missed dose as soon as possible but not if it is almost time for the next dose. If it is time for the next dose, skip the missed dose and resume your regular schedule. Do not double the dose to catch up.

Storage

Store at room temperature and keep away from moisture and sunlight. Do not store in the bathroom.