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MIDAZOLAM HCL
MIDAZOLAM - ORAL SYRUP

Important Note

The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

MIDAZOLAM - ORAL SYRUP

(mid-AZE-oh-lam)

COMMON BRAND NAME(S): Versed

WARNING: Use of midazolam can infrequently cause severe breathing problems (e.g., very slow, shallow breaths) which could cause brain damage or be fatal if left untreated. Therefore, this drug must be used only under close medical supervision. Also, it should only be used in a hospital or office (medical or dental) which is able to closely monitor your lung and heart function, and then correctly treat you if you develop any breathing problems.

Uses

This medication is used to relax and calm patients (generally children) before certain procedures, or before anesthesia for surgery. It also helps decrease memory of the event.

How To Use

This medication is given by mouth as directed. The patient's breathing, heart rate and blood pressure should be monitored at the time of administration, throughout the procedure and during the recovery period. The dosage is based on the patient's medical condition and response to the medication. Flumazenil is a medication that may be used to reverse the sedative effect of this drug.

Side Effects

Nausea, vomiting, dizziness and drowsiness may occur. If these effects persist or worsen, notify your doctor. Tell your doctor immediately if you have any of these unlikely but serious side effects: unusually slow or shallow breathing, unusually slow or fast heartbeat. Tell your doctor immediately if you have any of these very unlikely but serious side effects: mental/mood changes, fainting, muscle tremor. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.

Precautions

Tell your doctor your medical history, including: kidney or liver disorders, heart or lung disease, glaucoma (acute narrow-angle), allergies (especially to cherries or drugs). This drug will make you dizzy or drowsy; do not engage in activities requiring alertness such as driving or using machinery until one full day after anesthesia and surgery. Avoid alcoholic beverages. This medication is not recommended for use in the elderly since they may be more sensitive to the effects of the drug. Midazolam is not recommended for use during pregnancy. Discuss the risks and benefits with your doctor. This medication passes into breast milk. Consult your doctor before breast-feeding.

Drug Interactions

Tell your doctor of all prescription and nonprescription medication you may use, especially of: azole antifungals (e.g., fluconazole, itraconazole, ketoconazole), macrolide antibiotics (e.g., clarithromycin, erythromycin), protease inhibitors (e.g., ritonavir, nelfinavir), calcium channel blockers (e.g., diltiazem, verapamil), cimetidine, carbamazepine, phenytoin, rifamycins (e.g., rifampin). Also report the use of drugs that can drowsiness such as: sleeping pills, sedatives, tranquilizers, anti-anxiety drugs, narcotic pain relievers (e.g., codeine), psychiatric medicines, anti-seizure drugs, muscle relaxants, drowsiness-causing anti- histamines (e.g., diphenhydramine). Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. Do not eat grapefruit or drink grapefruit juice unless your doctor instructs you otherwise. Do not start or stop any medicine without doctor or pharmacist approval.

Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately.

Notes

Do not share this medication with others. Laboratory and/or medical tests will be performed to monitor your progress (e.g., breathing and blood pressure). Midazolam must be used as specified on the label. It is not for chronic or home use.

Missed Dose

Not applicable.

Storage

Store at room temperature 59 to 86 degrees F (15 to 30 degrees C) away from light and moisture.